Impaired Glucose Metabolism in Young Offspring of Female Rats with Hypothyroidism
Joint Authors
Xiao, Wei
Liu, Chao
Wang, Kun
Liu, Zhoujun
Chen, Yu
Chen, Guofang
Mao, Xiaodong
Li, Xingjia
Xu, Yijiao
Jiang, Fan
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Purpose.
Because thyroid hormones from the maternal thyroid glands are known to influence the growth, development, and metabolic functioning of offspring, we used a rat model to preliminarily investigate the effects of maternal hypothyroidism on glucose metabolism, pancreas cell proliferation, and insulin production in young male offspring and the possible underlying mechanisms.
Methods.
Female rats were divided into a maternal hypothyroidism (MH) group, which received water containing 0.02% 6-propyl-2-thiouracil before and during pregnancy to induce hypothyroidism, and a control group which consumed tap water.
Results.
Our results showed that there were no differences of islets structure between the offspring from the two groups, but glucose metabolism was impaired with higher plasma glucose concentrations at 0 and 15 min in the OGTT in 8-week-old offspring of the MH group.
From birth to 8 weeks, pancreatic TRβ1 and TRβ2 mRNA level declined significantly in MH offspring, accompanied by decreased Ki67 and insulin mRNA expression.
Conclusions.
Maternal hypothyroidism results in impaired pancreatic insulin synthesis and pancreatic cell proliferation in neonatal offspring and subsequent glucose intolerance in young offspring, which may be related to TRβ gene downregulation in the pancreas.
American Psychological Association (APA)
Liu, Zhoujun& Chen, Yu& Chen, Guofang& Mao, Xiaodong& Xiao, Wei& Li, Xingjia…[et al.]. 2019. Impaired Glucose Metabolism in Young Offspring of Female Rats with Hypothyroidism. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1172962
Modern Language Association (MLA)
Liu, Zhoujun…[et al.]. Impaired Glucose Metabolism in Young Offspring of Female Rats with Hypothyroidism. Journal of Diabetes Research No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1172962
American Medical Association (AMA)
Liu, Zhoujun& Chen, Yu& Chen, Guofang& Mao, Xiaodong& Xiao, Wei& Li, Xingjia…[et al.]. Impaired Glucose Metabolism in Young Offspring of Female Rats with Hypothyroidism. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1172962
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172962