Unlike PD-L1, PD-1 Is Downregulated on Partial Immune Cells in Type 2 Diabetes
Joint Authors
Sun, Peng
Jin, Qingyan
Nie, Shengnan
Jia, Shijie
Li, Yuanyuan
Li, Xiaoxue
Guo, Fang
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
Type 2 diabetes is a worldwide disease which is associated with chronic, low-grade inflammation.
The PD-1/PD-L1 pathway has been reported to be a negative regulatory element in immune homeostasis and to be involved in many diseases.
Materials and Methods.
Peripheral blood mononuclear cells (PBMCs) were obtained from type 2 diabetes patients (n=23) and healthy donors (n=20).
The PD-L1 and PD-1 expressions on corresponding immune cells were evaluated by flow cytometry.
Results.
The PD-L1 expression on corresponding immune cells has no significant difference between these two groups.
We showed the downregulated PD-1 expression in type 2 diabetes patients.
The correlation analysis indicated that the PD-1 on NK cells has a positive correlation with insulin and diabetes duration.
And an inverse correlation has been shown between the PD-1 expression on monocytes and BMI (body mass index).
Conclusions.
The results in this article suggest that PD-1, unlike PD-L1, might participate in the progression of type 2 diabetes.
This investigation will provide evidence for the potential immune therapy for T2D.
American Psychological Association (APA)
Sun, Peng& Jin, Qingyan& Nie, Shengnan& Jia, Shijie& Li, Yuanyuan& Li, Xiaoxue…[et al.]. 2019. Unlike PD-L1, PD-1 Is Downregulated on Partial Immune Cells in Type 2 Diabetes. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1172994
Modern Language Association (MLA)
Sun, Peng…[et al.]. Unlike PD-L1, PD-1 Is Downregulated on Partial Immune Cells in Type 2 Diabetes. Journal of Diabetes Research No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1172994
American Medical Association (AMA)
Sun, Peng& Jin, Qingyan& Nie, Shengnan& Jia, Shijie& Li, Yuanyuan& Li, Xiaoxue…[et al.]. Unlike PD-L1, PD-1 Is Downregulated on Partial Immune Cells in Type 2 Diabetes. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1172994
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172994