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Angiopoietins in Diabetic Retinopathy: Current Understanding and Therapeutic Potential
Joint Authors
Whitehead, Michael
Osborne, Andrew
Widdowson, Peter S.
Yu-Wai-Man, Patrick
Martin, Keith R.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Diabetic retinopathy (DR) is the commonest cause of blindness in the working-age population of the developed world.
The molecular pathophysiology of DR is complex, and a complete spatiotemporal model of the disease is still being elucidated.
Recently, a role for angiopoietin (Ang) proteins in the pathophysiology of DR has been proposed by several research groups, and several aspects of Ang signalling are being explored as novel therapeutic strategies.
Here, we review the role of the Ang proteins in two important forms of DR, diabetic macular oedema and proliferative diabetic retinopathy.
The function of the Ang proteins in regulating blood vessel permeability and neovascularisation is discussed, and we also evaluate recent preclinical and clinical studies highlighting the potential benefits of modulating Ang signalling as a treatment for DR.
American Psychological Association (APA)
Whitehead, Michael& Osborne, Andrew& Widdowson, Peter S.& Yu-Wai-Man, Patrick& Martin, Keith R.. 2019. Angiopoietins in Diabetic Retinopathy: Current Understanding and Therapeutic Potential. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1173000
Modern Language Association (MLA)
Whitehead, Michael…[et al.]. Angiopoietins in Diabetic Retinopathy: Current Understanding and Therapeutic Potential. Journal of Diabetes Research No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1173000
American Medical Association (AMA)
Whitehead, Michael& Osborne, Andrew& Widdowson, Peter S.& Yu-Wai-Man, Patrick& Martin, Keith R.. Angiopoietins in Diabetic Retinopathy: Current Understanding and Therapeutic Potential. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1173000
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173000