Dipeptidyl Peptidase 4 Activity Is Related to Body Composition, Measures of Adiposity, and Insulin Resistance in Subjects with Excessive Adiposity and Different Degrees of Glucose Tolerance
Joint Authors
Silva Júnior, Wellington Santana da
Kraemer-Aguiar, Luiz Guilherme
de Souza, Maria das Graças Coelho
Bouskela, Eliete
Nogueira Neto, José Firmino
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
The enzyme dipeptidyl peptidase 4 (DPP4) has been recently recognized as an adipo-myokine.
However, studies that associate its constitutive activity with body composition, anthropometry, and insulin resistance (IR) are very scarce and included only healthy people.
Methods.
First, we investigated the relationships of constitutive DPP4 activity, body composition (assessed by bioelectrical impedance analysis), and measures of adiposity and IR in fifty-two subjects of both sexes, 18-50 years, and BMI ≥25.0 kg/m2 who comprised three groups according to glucose tolerance.
Additionally, we evaluated associations among DPP4 activity and adipokines, gut peptides, and biochemical variables at fasting and 30 and 60 min after a standardized meal intake.
Results.
DPP4 activity was no different among the three groups.
At fasting, pooled analysis showed it was positively correlated with measures of central adiposity, such as WC (P=0.011) and WHR (P=0.009), and with all measures of IR, but inversely related to indexes of general adiposity, such as fat mass percentage (P=0.014) and BAI (P=0.0003).
DPP4 activity was also associated with lean mass (r=0.57, P<0.0001).
After meal intake, DPP4 activity remained significantly associated with insulin, leptin, and resistin.
In multiple regression analysis, BAI, WHR, percent lean mass, HOMA-IR, and leptin influenced DPP4 activity and explained approximately 26% of the variance on it.
Conclusions.
Constitutive DPP4 activity is positively associated with lean mass, central adiposity, and IR and negatively to general adiposity.
Furthermore, it seems to be influenced by body composition and IR and could also be viewed as an adipo-myokine in subjects with excessive adiposity and different stages of glucose tolerance.
American Psychological Association (APA)
Silva Júnior, Wellington Santana da& de Souza, Maria das Graças Coelho& Nogueira Neto, José Firmino& Bouskela, Eliete& Kraemer-Aguiar, Luiz Guilherme. 2019. Dipeptidyl Peptidase 4 Activity Is Related to Body Composition, Measures of Adiposity, and Insulin Resistance in Subjects with Excessive Adiposity and Different Degrees of Glucose Tolerance. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1173017
Modern Language Association (MLA)
Silva Júnior, Wellington Santana da…[et al.]. Dipeptidyl Peptidase 4 Activity Is Related to Body Composition, Measures of Adiposity, and Insulin Resistance in Subjects with Excessive Adiposity and Different Degrees of Glucose Tolerance. Journal of Diabetes Research No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1173017
American Medical Association (AMA)
Silva Júnior, Wellington Santana da& de Souza, Maria das Graças Coelho& Nogueira Neto, José Firmino& Bouskela, Eliete& Kraemer-Aguiar, Luiz Guilherme. Dipeptidyl Peptidase 4 Activity Is Related to Body Composition, Measures of Adiposity, and Insulin Resistance in Subjects with Excessive Adiposity and Different Degrees of Glucose Tolerance. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1173017
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173017