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Diabetes Mellitus, Nonalcoholic Fatty Liver Disease, and Conjugated Linoleic Acid (Omega 6): What Is the Link?
Joint Authors
Hegazy, Mona
Elsayed, Naglaa M.
Ali, Hala M.
Hassan, Hanan G.
Rashed, Laila
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background and Objective.
Type 2 DM and obesity are the coming epidemics and their association with NAFLD is well established; essential fatty acids are vital for body health yet the body cannot make them; 2 essential fatty acids are especially important: linoleic (omega-6) and alpha-linoleic (omega-3) acids; they can be considered as “bioactive lipids” and serve as functional foods.
Methods.
50 type 2 Egyptian diabetic patients controlled on oral hypoglycemic drugs together with 20 age- and sex-matched healthy participants were enrolled in the study; all were subjected to complete history taking, BMI, fasting plasma glucose, HOMA-IR, ALT, AST, GGT, urea and creatinine, total lipid profile, hepatitis markers including hepatitis B surface antigen and hepatitis C virus antibodies, conjugated linoleic fatty acid “CLA,” and abdominal ultrasound for grading of NAFLD.
Results.
Our study in Egyptian diabetics with NAFLD revealed a low level of serum CLA compared to healthy control; such deficiency was more marked with advanced grades of NAFLD; lowest levels were observed in those with severe steatosis (NASH) with definite association between CLA and obesity.
Conclusion.
Insulin resistance is the main link between NAFLD, diabetes, and obesity.
Conjugated linoleic acid (CLA) has a role in fat deposition in the liver and in development and improvement of insulin resistance.
Fatty food had a documented role in the pathogenesis of obesity and diabetes but it can also be the cure.
American Psychological Association (APA)
Hegazy, Mona& Elsayed, Naglaa M.& Ali, Hala M.& Hassan, Hanan G.& Rashed, Laila. 2019. Diabetes Mellitus, Nonalcoholic Fatty Liver Disease, and Conjugated Linoleic Acid (Omega 6): What Is the Link?. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1173020
Modern Language Association (MLA)
Hegazy, Mona…[et al.]. Diabetes Mellitus, Nonalcoholic Fatty Liver Disease, and Conjugated Linoleic Acid (Omega 6): What Is the Link?. Journal of Diabetes Research No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1173020
American Medical Association (AMA)
Hegazy, Mona& Elsayed, Naglaa M.& Ali, Hala M.& Hassan, Hanan G.& Rashed, Laila. Diabetes Mellitus, Nonalcoholic Fatty Liver Disease, and Conjugated Linoleic Acid (Omega 6): What Is the Link?. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1173020
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173020