Static Magnetic Field Accelerates Diabetic Wound Healing by Facilitating Resolution of Inflammation
Joint Authors
Yu, Ying
Shang, Wenlong
Chen, Guilin
Li, Yinxiu
Zhuo, Yujuan
Wang, Yuhong
Fang, Zhicai
Ren, Huiwen
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Impaired wound healing is commonly encountered in patients with diabetes mellitus, which may lead to severe outcomes such as amputation, if untreated timely.
Macrophage plays a critical role in the healing process including the resolution phase.
Although magnetic therapy is known to improve microcirculation, its effect on wound healing remains uncertain.
In the present study, we found that 0.6 T static magnetic field (SMF) significantly accelerated wound closure and elevated reepithelialization and revascularization in diabetic mice.
Notably, SMF promoted the wound healing by skewing the macrophage polarization towards M2 phenotype, thus facilitating the resolution of inflammation.
In addition, SMF upregulated anti-inflammatory gene expression via activating STAT6 and suppressing STAT1 in macrophage.
Taken together, our results indicate that SMF may be a promising adjuvant therapeutic tool for treating diabetic wounds.
American Psychological Association (APA)
Shang, Wenlong& Chen, Guilin& Li, Yinxiu& Zhuo, Yujuan& Wang, Yuhong& Fang, Zhicai…[et al.]. 2019. Static Magnetic Field Accelerates Diabetic Wound Healing by Facilitating Resolution of Inflammation. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1173061
Modern Language Association (MLA)
Shang, Wenlong…[et al.]. Static Magnetic Field Accelerates Diabetic Wound Healing by Facilitating Resolution of Inflammation. Journal of Diabetes Research No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1173061
American Medical Association (AMA)
Shang, Wenlong& Chen, Guilin& Li, Yinxiu& Zhuo, Yujuan& Wang, Yuhong& Fang, Zhicai…[et al.]. Static Magnetic Field Accelerates Diabetic Wound Healing by Facilitating Resolution of Inflammation. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1173061
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173061