Hepatotoxicity of Nonsteroidal Anti-Inflammatory Drugs: A Systematic Review of Randomized Controlled Trials
Joint Authors
Sriuttha, Pajaree
Sirichanchuen, Buntitabhon
Permsuwan, Unchalee
Source
International Journal of Hepatology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-15
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Background.
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most widely used medication in several countries, including Thailand.
NSAIDs have been associated with hepatic side effects; however, the frequency of these side effects is uncertain.
Aim of the Review.
To systematically review published literature on randomized, controlled trials that assessed the risk of clinically significant hepatotoxicity associated with NSAIDs.
Methods.
Searches of bibliographic databases EMBASE, PubMed, and the Cochrane Library were conducted up to July 30, 2016, to identify randomized controlled trials of ibuprofen, naproxen, diclofenac, piroxicam, meloxicam, mefenamic acid, indomethacin, celecoxib, and etoricoxib in adults with any disease that provide information on hepatotoxicity outcomes.
Results.
Among the 698 studies, 18 studies met the selection criteria.
However, only 8 studies regarding three NSAIDs (celecoxib, etoricoxib, and diclofenac) demonstrated clinically significant hepatotoxic evidence based on hepatotoxicity justification criteria.
Of all the hepatotoxicity events found from the above-mentioned three NSAIDs, diclofenac had the highest proportion, which ranged from 0.015 to 4.3 (×10−2), followed by celecoxib, which ranged from 0.13 to 0.38 (×10−2), and etoricoxib, which ranged from 0.005 to 0.930 (×10−2).
Conclusion.
Diclofenac had higher rates of hepatotoxic evidence compared to other NSAIDs.
Hepatotoxic evidence is mostly demonstrated as aminotransferase elevation, while liver-related hospitalization or discontinuation was very low.
American Psychological Association (APA)
Sriuttha, Pajaree& Sirichanchuen, Buntitabhon& Permsuwan, Unchalee. 2018. Hepatotoxicity of Nonsteroidal Anti-Inflammatory Drugs: A Systematic Review of Randomized Controlled Trials. International Journal of Hepatology،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1173062
Modern Language Association (MLA)
Sriuttha, Pajaree…[et al.]. Hepatotoxicity of Nonsteroidal Anti-Inflammatory Drugs: A Systematic Review of Randomized Controlled Trials. International Journal of Hepatology No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1173062
American Medical Association (AMA)
Sriuttha, Pajaree& Sirichanchuen, Buntitabhon& Permsuwan, Unchalee. Hepatotoxicity of Nonsteroidal Anti-Inflammatory Drugs: A Systematic Review of Randomized Controlled Trials. International Journal of Hepatology. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1173062
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173062