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Vitamin D Supplementation and Cognition in People with Type 2 Diabetes: A Randomized Control Trial
Joint Authors
Byrn, Mary A.
Adams, William
Penckofer, Sue
Emanuele, Mary Ann
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-30
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Aim.
Type 2 diabetes increases the risk of cognitive decline which adversely impacts self-management of the disease.
Evidence also supports a relationship between low serum 25(OH)D levels and poor cognition.
The purpose of this trial was to assess vitamin D supplementation on cognitive executive functioning in persons living with type 2 diabetes.
Methods.
This was a double-blinded RCT where participants were randomized to receive either weekly vitamin D3 supplementation (50,000 IUs) or a matching comparator (5,000 IUs) for three months.
The primary outcome was a battery of neuropsychological tests.
Serum 25(OH)D was measured by liquid chromatography/tandem mass spectrometry.
Repeated assessments of cognitive measures were collected over 12 weeks using alternative testing forms to minimize practice effects.
Results.
Thirty participants were randomized to either the low-dose allocation (n=15) or the high-dose allocation (n=15).
Most participants were female (83%) and identified as Black (57%).
For all cognition measures, there was no statistically significant finding between participants who received high-dose vitamin D supplementation and those who received low-dose supplementation.
However, when assessing cognitive function in both groups over time, minimal improvement on the Symbol-Digits, the Stroop Interference Test, and the Trail Making Test Part B was observed.
Conclusions.
To our knowledge, this is the first randomized control trial to examine the effects of vitamin D supplementation on cognitive function in people with type 2 diabetes.
However, no significant differences in cognitive outcomes between participants who received high-dose therapy and those who received low dose were found.
American Psychological Association (APA)
Byrn, Mary A.& Adams, William& Penckofer, Sue& Emanuele, Mary Ann. 2019. Vitamin D Supplementation and Cognition in People with Type 2 Diabetes: A Randomized Control Trial. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1173064
Modern Language Association (MLA)
Byrn, Mary A.…[et al.]. Vitamin D Supplementation and Cognition in People with Type 2 Diabetes: A Randomized Control Trial. Journal of Diabetes Research No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1173064
American Medical Association (AMA)
Byrn, Mary A.& Adams, William& Penckofer, Sue& Emanuele, Mary Ann. Vitamin D Supplementation and Cognition in People with Type 2 Diabetes: A Randomized Control Trial. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1173064
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173064