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Oral Fludrocortisone Test for Salt-Sensitive Screening in Hypertensive Patients: A Randomized Crossover Trial
Joint Authors
Pio-Abreu, Andrea
de Castro, Isac
da Silva, Giovanio Vieira
Ortega, Katia Coelho
Mion, Decio
Source
International Journal of Hypertension
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Salt sensitivity is associated with an increased cardiovascular risk, but the gold standard method (diet cycles) requires 24-h urine samples and has poor patient compliance.
Objectives.
Test the hypothesis that oral fludrocortisone (0.4 mg per day for 7 days) is a good alternative in identifying salt-sensitive patients.
Methodology.
We conducted a randomized crossover study with 30 hypertensive individuals comprising the following steps: (1) washout; (2) phase A (low- and high-sodium diet cycles); (3) washout 2; (4) phase B (fludrocortisone test).
Phase A and B steps were performed in a random way.
Consistent with the literature, we found that 53.3% were salt-sensitive according to the reference test.
Using the ROC curve, the fludrocortisone test defined salt sensitivity by a median blood pressure increase of ≥3 mmHg.
A good accuracy of fludrocortisone in detecting salt sensitivity was observed (AUC: 0.732±0.065; p<0.001), with 80% sensitivity and 53% specificity.
Conclusion.
The fludrocortisone test is a good option for screening salt sensitivity in hypertensive patients.
However, the low specificity prevents this test from being an ideal substitute to the labor-intensive diet cycles exam in the definition of salt sensitivity.
This clinical trial is registered with NCT01453959.
American Psychological Association (APA)
Pio-Abreu, Andrea& de Castro, Isac& da Silva, Giovanio Vieira& Ortega, Katia Coelho& Mion, Decio. 2018. Oral Fludrocortisone Test for Salt-Sensitive Screening in Hypertensive Patients: A Randomized Crossover Trial. International Journal of Hypertension،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1173179
Modern Language Association (MLA)
Pio-Abreu, Andrea…[et al.]. Oral Fludrocortisone Test for Salt-Sensitive Screening in Hypertensive Patients: A Randomized Crossover Trial. International Journal of Hypertension No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1173179
American Medical Association (AMA)
Pio-Abreu, Andrea& de Castro, Isac& da Silva, Giovanio Vieira& Ortega, Katia Coelho& Mion, Decio. Oral Fludrocortisone Test for Salt-Sensitive Screening in Hypertensive Patients: A Randomized Crossover Trial. International Journal of Hypertension. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1173179
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173179