The Significance of an Increased Beta-Hydroxybutyrate at Presentation to the Emergency Department in Patients with Diabetes in the Absence of a Hyperglycemic Emergency
Joint Authors
Depczynski, Barbara
Lee, Alexandra Tze Kiu
Varndell, Wayne
Chiew, Angela L.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The significance of hyperketonemia in adults with diabetes presenting to the emergency department with acute illness, not due to a diabetic hyperglycemic emergency, has not been well characterized.
Adult patients with diabetes presenting to the emergency department who had venous blood gas and beta-hydroxybutyrate levels measured whilst in the emergency department were retrospectively evaluated for the relationship between BHB and clinical outcomes.
Over 6 months, 404 patients with diabetes had at least one beta-hydroxybutyrate level measured in the emergency department.
There were 23 admissions for diabetic ketoacidosis (DKA) or hyperosmolar state.
Of the remainder, 58 patients had a beta-hydroxybutyrate≥1 mmol/L; this group had a higher glucose at presentation (19.0 (8.8) versus 10.4 (9.9) mmol/L), higher HbA1c (8.8 (5.4) versus 8.0 (3.3)%), lower bicarbonate (22.6 (6.2) versus 24.8 (4.7) mmol/L), and higher anion gap (14.8 (6.1) versus 12.6 (4.2)) than had those with BHB<1 mmol/L.
There was no association between the presence of ketosis and the length of stay (4.2 (7.3) versus (3.0) (7.2) days).
Acute illness in those with diabetes associated with ketosis in the absence of DKA is associated with worse glycaemic control than in those without ketosis.
Ketosis may represent an intermediate state of metabolic dysregulation rather than being associated with a more severe acute illness, as suggested by no relationship between BHB and length of stay.
American Psychological Association (APA)
Depczynski, Barbara& Lee, Alexandra Tze Kiu& Varndell, Wayne& Chiew, Angela L.. 2019. The Significance of an Increased Beta-Hydroxybutyrate at Presentation to the Emergency Department in Patients with Diabetes in the Absence of a Hyperglycemic Emergency. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1173185
Modern Language Association (MLA)
Depczynski, Barbara…[et al.]. The Significance of an Increased Beta-Hydroxybutyrate at Presentation to the Emergency Department in Patients with Diabetes in the Absence of a Hyperglycemic Emergency. Journal of Diabetes Research No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1173185
American Medical Association (AMA)
Depczynski, Barbara& Lee, Alexandra Tze Kiu& Varndell, Wayne& Chiew, Angela L.. The Significance of an Increased Beta-Hydroxybutyrate at Presentation to the Emergency Department in Patients with Diabetes in the Absence of a Hyperglycemic Emergency. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1173185
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173185