Association of Elevated Serum GM-CSF, IFN-γ, IL-4, and TNF-α Concentration with Tobacco Smoke Induced Chronic Obstructive Pulmonary Disease in a South Indian Population
Joint Authors
Vishweswaraiah, Sangeetha
Thimraj, Tania Ahalya
Krishnarao, Chaya Sindaghatta
Lokesh, Komarla Sundararaja
Siddaiah, Jayaraj Biligere
Ganguly, Koustav
Mitra, Ankita
Maheswarappa, Mahendra
Padukudru Anand, Mahesh
Source
International Journal of Inflammation
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Chronic obstructive pulmonary disease (COPD) is a devastating condition with limited pharmacotherapeutic options and exceptionally high public-health burden globally as well as in India.
Tobacco smoking is the primary cause for COPD among men in India.
Systemic inflammation involving altered regulation of cytokines controlling the host defense mechanism is a hallmark of COPD pathogenesis.
However, biomarker discovery studies are limited among Indian COPD patients.
Methods.
We assessed the serum concentrations [median (25th-75th percentile) pg/ml] of interleukin (IL)-2,4,6,8,10, granulocyte macrophage colony stimulating factor (GM-CSF), interferon gamma (IFN-γ), and tumor necrosis factor alpha (TNF-α) using a multiplexed immunoassay.
Our study cohort consisted of 30 tobacco smokers with COPD (TS COPD) and 20 tobacco smokers without COPD (TS CONTROL) from South India.
The study population was matched for age, sex (male), and tobacco consumption (pack-years).
COPD was diagnosed according to the global initiative for chronic obstructive lung disease (GOLD) criteria of persistent airflow obstruction determined by the ratio of postbronchodilator forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC) of <0.7.
A validated structured questionnaire-based survey [Burden of Obstructive Lung Disease (BOLD) study] and spirometry were performed during house to house visit of the field study.
Statistical analysis included nonparametric (two-tailed) Mann–Whitney U and Spearman rank test, as appropriate (significance: p<0.05).
Results.
Serum GM-CSF [69.64 (46.67, 97.48); 36.78 (30.07, 53.88), p=0.014], IFN-γ [51.06 (17.00, 84.86); 11.70 (3.18, 32.81), p=0.017], IL-4 [9.09 (1.8, 19.9); 1.8 (1.8, 4.46); p=0.024], and TNF-α [20.68 (5.5, 29.26); 3.5 (3.5, 4.5); p<0.001] concentrations (pg/ml) were increased in TS COPD subjects compared to TS CONTROL.
A weak correlation between lung function parameters and cytokine concentrations was detected.
Conclusion.
Our pilot study reveals GM-CSF, IFN-γ, IL-4, and TNF-α as plausible COPD susceptibility biomarkers within the investigated South Indian population that needs to be validated in a larger cohort.
American Psychological Association (APA)
Mitra, Ankita& Vishweswaraiah, Sangeetha& Thimraj, Tania Ahalya& Maheswarappa, Mahendra& Krishnarao, Chaya Sindaghatta& Lokesh, Komarla Sundararaja…[et al.]. 2018. Association of Elevated Serum GM-CSF, IFN-γ, IL-4, and TNF-α Concentration with Tobacco Smoke Induced Chronic Obstructive Pulmonary Disease in a South Indian Population. International Journal of Inflammation،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1173240
Modern Language Association (MLA)
Mitra, Ankita…[et al.]. Association of Elevated Serum GM-CSF, IFN-γ, IL-4, and TNF-α Concentration with Tobacco Smoke Induced Chronic Obstructive Pulmonary Disease in a South Indian Population. International Journal of Inflammation No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1173240
American Medical Association (AMA)
Mitra, Ankita& Vishweswaraiah, Sangeetha& Thimraj, Tania Ahalya& Maheswarappa, Mahendra& Krishnarao, Chaya Sindaghatta& Lokesh, Komarla Sundararaja…[et al.]. Association of Elevated Serum GM-CSF, IFN-γ, IL-4, and TNF-α Concentration with Tobacco Smoke Induced Chronic Obstructive Pulmonary Disease in a South Indian Population. International Journal of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1173240
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173240