Impaired Inflammatory Response to LPS in Type 2 Diabetes Mellitus
Joint Authors
Manukyan, Gayane
Khondkaryan, Lusine
Margaryan, Sona
Poghosyan, David
Source
International Journal of Inflammation
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Type 2 diabetes mellitus (T2DM) is a severe health problem worldwide, reaching epidemic levels.
High susceptibility to infections of T2DM patients indicates dysregulated immune responses to pathogens.
However, innate immune responses, including monocyte functions, in T2DM are poorly investigated.
Therefore, in this study we aimed to assess lipopolysaccharide- (LPS-) induced immune responses of circulating monocytes from T2DM patients.
The results showed that monocytes from T2DM were hyporesponsive to LPS challenge as reflected by significantly suppressed secretion of TNFα (p<0.01) and expression of CD11b (p<0.001) and TLR4 (p<0.001) compared to those in monocytes from healthy subjects.
Furthermore, LPS-induced IL-10 levels were similar in diabetic and healthy supernatants, while expression levels of CD163 were found to be downregulated on monocytes from T2DM (p<0.001) suggesting impaired ability of monocytes to switch their phenotype to anti-inflammatory.
Taken together, our results suggest compromised function of monocytes in T2DM, which may explain, at least partly, high incidence of infection in these patients.
American Psychological Association (APA)
Khondkaryan, Lusine& Margaryan, Sona& Poghosyan, David& Manukyan, Gayane. 2018. Impaired Inflammatory Response to LPS in Type 2 Diabetes Mellitus. International Journal of Inflammation،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1173243
Modern Language Association (MLA)
Khondkaryan, Lusine…[et al.]. Impaired Inflammatory Response to LPS in Type 2 Diabetes Mellitus. International Journal of Inflammation No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1173243
American Medical Association (AMA)
Khondkaryan, Lusine& Margaryan, Sona& Poghosyan, David& Manukyan, Gayane. Impaired Inflammatory Response to LPS in Type 2 Diabetes Mellitus. International Journal of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1173243
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173243