Vitamin D3 Activates Phosphatidylinositol-3-KinaseProtein Kinase B via Insulin-Like Growth Factor-1 to Improve Testicular Function in Diabetic Rats
Joint Authors
Qin, Guijun
Wang, Qingzhu
Guo, Feng
He, Yanyan
Liu, Yang
Huang, Fengjuan
Ji, Linlin
An, Tingting
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
In diabetes mellitus, vitamin D3 deficiency affects sex hormone levels and male fertility; however, the mechanism leading to the disorder is unclear.
This research was designed to investigate the mechanism of vitamin D3 deficiency and hypogonadism in diabetic rats.
Our aim was to assess serum vitamin D3 levels and the relationship among vitamin D3, insulin-like growth factor-1 (IGF-1), and testicular function.
Materials and Methods.
Rats with streptozotocin-induced diabetes were randomly divided into four groups and treated with different doses of vitamin D3: no vitamin D3, low (0.025 μg/kg/day), high (0.1 μg/kg/day), and high (0.1 μg/kg/day) with JB-1 (the insulin-like growth factor-1 receptor inhibitor group, 100 μg/kg/day).
The groups were compared with wild-type rats, which function as the control group.
Various parameters such as vitamin D3 and IGF-1 were compared between the experimental and wild-type groups, and their correlations were determined.
Results.
Twelve weeks of vitamin D3 supplementation improved the testosterone levels, as shown by the increase in the level of serum IGF-1 in diabetic rats.
Phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT), which was a downstream of the signaling pathway of IGF-1, was significantly increased after vitamin D3 treatment.
Conclusions.
The study shows that vitamin D3 may promote the expression of testosterone and improve testicular function in diabetic rats by activating PI3K/AKT via IGF-1.
American Psychological Association (APA)
He, Yanyan& Liu, Yang& Wang, Qingzhu& Guo, Feng& Huang, Fengjuan& Ji, Linlin…[et al.]. 2019. Vitamin D3 Activates Phosphatidylinositol-3-KinaseProtein Kinase B via Insulin-Like Growth Factor-1 to Improve Testicular Function in Diabetic Rats. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1173244
Modern Language Association (MLA)
He, Yanyan…[et al.]. Vitamin D3 Activates Phosphatidylinositol-3-KinaseProtein Kinase B via Insulin-Like Growth Factor-1 to Improve Testicular Function in Diabetic Rats. Journal of Diabetes Research No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1173244
American Medical Association (AMA)
He, Yanyan& Liu, Yang& Wang, Qingzhu& Guo, Feng& Huang, Fengjuan& Ji, Linlin…[et al.]. Vitamin D3 Activates Phosphatidylinositol-3-KinaseProtein Kinase B via Insulin-Like Growth Factor-1 to Improve Testicular Function in Diabetic Rats. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1173244
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173244