Natural Products with Toll-Like Receptor 4 Antagonist Activity
Joint Authors
Molteni, Monica
Rossetti, Carlo
Bosi, Annalisa
Source
International Journal of Inflammation
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Toll-Like Receptors (TLRs) are the innate immunity receptors that play an activating role when interacting with molecules released by bacteria and viruses (PAMPs, pathogen-associated molecular patterns) or with molecules released by injured cells and tissues (DAMPs, danger-associated molecular patterns).
TLR triggering leads to the induction of proinflammatory cytokines and chemokines, driving the activation of both innate and adaptive immunity.
In particular, Toll-Like Receptor 4 (TLR4) has been described to be involved in the inflammatory processes observed in several pathologies (such as ischemia/reperfusion injury, neuropathic pain, neurodegenerative diseases, and cancer).
Molecules obtained by natural sources have been discovered to exert an anti-inflammatory action by targeting TLR4 activation pathways.
This review focuses on TLR4 antagonists obtained from bacteria, cyanobacteria, and plants.
American Psychological Association (APA)
Molteni, Monica& Bosi, Annalisa& Rossetti, Carlo. 2018. Natural Products with Toll-Like Receptor 4 Antagonist Activity. International Journal of Inflammation،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1173245
Modern Language Association (MLA)
Molteni, Monica…[et al.]. Natural Products with Toll-Like Receptor 4 Antagonist Activity. International Journal of Inflammation No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1173245
American Medical Association (AMA)
Molteni, Monica& Bosi, Annalisa& Rossetti, Carlo. Natural Products with Toll-Like Receptor 4 Antagonist Activity. International Journal of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1173245
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173245