Sleep-Disordered Breathing Is Associated with Metabolic Syndrome in Outpatients with Diabetes Mellitus Type 2

Abstract EN

Background.

Metabolic syndrome (MS) and sleep-disordered breathing (SDB) are highly prevalent in patients with diabetes mellitus type 2 (DM2).

The present study examined whether there is an independent association between SDB and MS in a sample of outpatients with DM2.

Methods.

MS was determined in 679 patients of the DIACORE-SDB substudy, a study of outpatients with DM2.

According to the National Cholesterol Education Program (NCEP) criteria, MS is defined by at least three of the following five criteria: waist circumference of >102 cm (men)/>88 cm (women), blood pressure of ≥130/85 mmHg, a fasting triglyceride level of >150 mg/dl, high-density lipoprotein (HDL) of <40 mg/dl (men)/<50 mg/dl (women), and a fasting glucose level of ≥110 mg/dl.

The apnea-hypopnea index (AHI) was assessed with a 2-channel ambulatory monitoring device and used to define the severity of SDB (AHI<15.0: no/mild SDB; AHI 15.0-29.9: moderate SDB; AHI≥30.0: severe SDB).

Results.

228 (34%) of the 679 participants (mean age 66 years, mean body mass index (BMI) 31.2 kg/m2, and mean AHI 14/hour) had SDB.

MS was significantly more frequent in patients with more severe SDB (no/mild SDB vs.

moderate SDB vs.

severe SDB: 72% vs.

79% vs.

85%, respectively, p=0.038).

Logistic regression analysis adjusted for sex, age, obesity (BMI≥30 kg/m2), and the HOMA index showed a significant association between the AHI and the presence of MS (OR 95%CI=1.039 (1.011; 1.068); p=0.007).

Further, male sex, obesity, and the HOMA index were significantly associated with MS.

Conclusion.

SDB is significantly and independently associated with MS in outpatients with DM2.