Melatonin Affects Mitochondrial FissionFusion Dynamics in the Diabetic Retina
Joint Authors
Shi, Liheng
Ko, Michael L.
Ko, Gladys Y.-P.
Chang, Janet Ya-An
Yu, Fei
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-11
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Mitochondrial fission and fusion are dependent on cellular nutritional states, and maintaining this dynamics is critical for the health of cells.
Starvation triggers mitochondrial fusion to maintain bioenergetic efficiency, but during nutrient overloads (as with hyperglycemic conditions), fragmenting mitochondria is a way to store nutrients to avoid waste of energy.
In addition to ATP production, mitochondria play an important role in buffering intracellular calcium (Ca2+).
We found that in cultured 661W cells, a photoreceptor-derived cell line, hyperglycemic conditions triggered an increase of the expression of dynamin-related protein 1 (DRP1), a protein marker of mitochondrial fission, and a decrease of mitofusin 2 (MFN2), a protein for mitochondrial fusion.
Further, these hyperglycemic cells also had decreased mitochondrial Ca2+ but increased cytosolic Ca2+.
Treating these hyperglycemic cells with melatonin, a multifaceted antioxidant, averted hyperglycemia-altered mitochondrial fission-and-fusion dynamics and mitochondrial Ca2+ levels.
To mimic how people most commonly take melatonin supplements, we gave melatonin to streptozotocin- (STZ-) induced type 1 diabetic mice by daily oral gavage and determined the effects of melatonin on diabetic eyes.
We found that melatonin was not able to reverse the STZ-induced systemic hyperglycemic condition, but it prevented STZ-induced damage to the neural retina and retinal microvasculature.
The beneficial effects of melatonin in the neural retina in part were through alleviating STZ-caused changes in mitochondrial dynamics and Ca2+ buffering.
American Psychological Association (APA)
Chang, Janet Ya-An& Yu, Fei& Shi, Liheng& Ko, Michael L.& Ko, Gladys Y.-P.. 2019. Melatonin Affects Mitochondrial FissionFusion Dynamics in the Diabetic Retina. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1173288
Modern Language Association (MLA)
Chang, Janet Ya-An…[et al.]. Melatonin Affects Mitochondrial FissionFusion Dynamics in the Diabetic Retina. Journal of Diabetes Research No. 2019 (2019), pp.1-17.
https://search.emarefa.net/detail/BIM-1173288
American Medical Association (AMA)
Chang, Janet Ya-An& Yu, Fei& Shi, Liheng& Ko, Michael L.& Ko, Gladys Y.-P.. Melatonin Affects Mitochondrial FissionFusion Dynamics in the Diabetic Retina. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1173288
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173288