Enterococcus faecium TIR-Domain Genes Are Part of a Gene Cluster Which Promotes Bacterial Survival in Blood

Joint Authors

Wagner, Theresa M.
Janice, Jessin
Paganelli, Fernanda L.
Willems, Rob J.
Askarian, Fatemeh
Pedersen, Torunn
Top, Janetta
de Haas, Carla
van Strijp, Jos A.
Johannessen, Mona
Hegstad, Kristin

Source

International Journal of Microbiology

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-17, 17 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-12-03

Country of Publication

Egypt

No. of Pages

17

Main Subjects

Medicine

Abstract EN

Enterococcus faecium has undergone a transition to a multidrug-resistant nosocomial pathogen.

The population structure of E.

faecium is characterized by a sharp distinction of clades, where the hospital-adapted lineage is primarily responsible for bacteremia.

So far, factors that were identified in hospital-adapted strains and that promoted pathogenesis of nosocomial E.

faecium mainly play a role in adherence and biofilm production, while less is known about factors contributing to survival in blood.

This study identified a gene cluster, which includes genes encoding bacterial Toll/interleukin-1 receptor- (TIR-) domain-containing proteins (TirEs).

The cluster was found to be unique to nosocomial strains and to be located on a putative mobile genetic element of phage origin.

The three genes within the cluster appeared to be expressed as an operon.

Expression was detected in bacterial culture media and in the presence of human blood.

TirEs are released into the bacterial supernatant, and TirE2 is associated with membrane vesicles.

Furthermore, the tirE-gene cluster promotes bacterial proliferation in human blood, indicating that TirE may contribute to the pathogenesis of bacteremia.

American Psychological Association (APA)

Wagner, Theresa M.& Janice, Jessin& Paganelli, Fernanda L.& Willems, Rob J.& Askarian, Fatemeh& Pedersen, Torunn…[et al.]. 2018. Enterococcus faecium TIR-Domain Genes Are Part of a Gene Cluster Which Promotes Bacterial Survival in Blood. International Journal of Microbiology،Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1173289

Modern Language Association (MLA)

Wagner, Theresa M.…[et al.]. Enterococcus faecium TIR-Domain Genes Are Part of a Gene Cluster Which Promotes Bacterial Survival in Blood. International Journal of Microbiology No. 2018 (2018), pp.1-17.
https://search.emarefa.net/detail/BIM-1173289

American Medical Association (AMA)

Wagner, Theresa M.& Janice, Jessin& Paganelli, Fernanda L.& Willems, Rob J.& Askarian, Fatemeh& Pedersen, Torunn…[et al.]. Enterococcus faecium TIR-Domain Genes Are Part of a Gene Cluster Which Promotes Bacterial Survival in Blood. International Journal of Microbiology. 2018. Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1173289

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1173289