Chinese Herbal Medicine in Ameliorating Diabetic Kidney Disease via Activating Autophagy
Joint Authors
Zhan, Yongli
Li, Ping
Zhao, Hailing
Wang, Yuyang
Wang, Qian
Zhou, Xuefeng
Lu, Xiaoguang
Liu, Tongtong
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Diabetic kidney disease (DKD), a leading cause of end-stage renal disease (ESRD), has become a serious public health problem worldwide and lacks effective therapies due to its complex pathogenesis.
Recent studies suggested defective autophagy involved in the pathogenesis and progression of DKD.
Chinese herbal medicine, as an emerging option for the treatment of DKD, could improve diabetic kidney injury by activating autophagy.
In this review, we briefly summarize underlying mechanisms of autophagy dysregulation in DKD, including AMP-activated protein kinase (AMPK), the mechanistic target of rapamycin (mTOR), and the sirtuin (Sirt) pathways, and we particularly concentrate on the current status of Chinese herbal medicine treating DKD by regulating autophagy.
The advances in our understanding regarding the treatment of DKD via regulating autophagy with Chinese herbal medicine will enhance the clinical application of Chinese medicine as well as discovery of novel therapeutic agents for diabetic patients.
American Psychological Association (APA)
Wang, Yuyang& Zhao, Hailing& Wang, Qian& Zhou, Xuefeng& Lu, Xiaoguang& Liu, Tongtong…[et al.]. 2019. Chinese Herbal Medicine in Ameliorating Diabetic Kidney Disease via Activating Autophagy. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1173356
Modern Language Association (MLA)
Wang, Yuyang…[et al.]. Chinese Herbal Medicine in Ameliorating Diabetic Kidney Disease via Activating Autophagy. Journal of Diabetes Research No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1173356
American Medical Association (AMA)
Wang, Yuyang& Zhao, Hailing& Wang, Qian& Zhou, Xuefeng& Lu, Xiaoguang& Liu, Tongtong…[et al.]. Chinese Herbal Medicine in Ameliorating Diabetic Kidney Disease via Activating Autophagy. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1173356
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173356