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Association of Tumor Necrosis Factor Alpha, Interleukin 6, and C-Reactive Protein with the Risk of Developing Type 2 Diabetes: A Retrospective Cohort Study of Rural Thais
Joint Authors
Lainampetch, Jirayu
Panprathip, Pornpimol
Phosat, Chanchira
Chumpathat, Noppanath
Prangthip, Pattaneeya
Soonthornworasiri, Ngamphol
Puduang, Somchai
Wechjakwen, Naruemon
Kwanbunjan, Karunee
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The linkage of obesity, inflammation, and type 2 diabetes mellitus (T2DM) has been extensively investigated for over a decade.
However, the association between inflammatory biomarkers, including C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α), and T2DM is still inconsistent and limited.
Thus, this study is aimed at elucidating the association between inflammatory marker levels and the risk of developing T2DM in many aspects.
Among 296 subjects enrolled in 2013, 248 non-T2DM subjects who were completely reinvestigated in 2014 and 2015 were included in a 2-year retrospective analysis.
Multivariate logistic regression was performed to evaluate the association of baseline inflammatory marker levels and variation with incidence of T2DM.
After the 2-year follow-up, 18.6% of total subjects had developed T2DM.
The risk of developing T2DM was significantly increased in subjects with a high level of baseline CRP (OR=4.02, 95% CI: 1.77-9.12, P=0.001), and a stronger impact was found with the combination of high CRP and IL-6 levels (OR=5.11, 95% CI: 1.27-20.49, P=0.021).
One-year inflammatory marker variation analysis also revealed the significant association of elevated TNF-α and risk of developing T2DM (OR=4.88, 95% CI: 1.01-23.49, P=0.048).
In conclusion, besides consideration of CRP levels alone, our findings suggested that IL-6 outstandingly plays a contributing role in T2DM progression and elevated TNF-α levels over time could be a potential predictor of T2DM.
American Psychological Association (APA)
Lainampetch, Jirayu& Panprathip, Pornpimol& Phosat, Chanchira& Chumpathat, Noppanath& Prangthip, Pattaneeya& Soonthornworasiri, Ngamphol…[et al.]. 2019. Association of Tumor Necrosis Factor Alpha, Interleukin 6, and C-Reactive Protein with the Risk of Developing Type 2 Diabetes: A Retrospective Cohort Study of Rural Thais. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1173365
Modern Language Association (MLA)
Lainampetch, Jirayu…[et al.]. Association of Tumor Necrosis Factor Alpha, Interleukin 6, and C-Reactive Protein with the Risk of Developing Type 2 Diabetes: A Retrospective Cohort Study of Rural Thais. Journal of Diabetes Research No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1173365
American Medical Association (AMA)
Lainampetch, Jirayu& Panprathip, Pornpimol& Phosat, Chanchira& Chumpathat, Noppanath& Prangthip, Pattaneeya& Soonthornworasiri, Ngamphol…[et al.]. Association of Tumor Necrosis Factor Alpha, Interleukin 6, and C-Reactive Protein with the Risk of Developing Type 2 Diabetes: A Retrospective Cohort Study of Rural Thais. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1173365
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173365