Triazole-Resistant Aspergillus fumigatus from Fungicide-Experienced Soils in Naivasha Subcounty and Nairobi County, Kenya

Joint Authors

Nyerere, Andrew
Bii, Christine C.
Kemoi, Edson K.

Source

International Journal of Microbiology

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-06-26

Country of Publication

Egypt

No. of Pages

6

Main Subjects

Medicine

Abstract EN

The mainstay in prevention and treatment of aspergillosis is the use triazole drugs.

In Kenya, the use of agricultural azole is one of the predisposing factors in development of resistance.

One hundred fifty-six (156) experienced soils were collected from agricultural farms and cultured on Sabouraud DextroseAagar.

The study isolated 48 yielded Aspergillus fumigatus and 2 A.

flavus.

All the isolates were subjected to antifungal susceptibility testing against three triazoles: posaconazole, voriconazole, and itraconazole.

Out of the isolates, 3 had MIC of 32 and 1 had MIC of 16 against itraconazole, and 1 isolate had MIC of 32 against posaconazole.

CYP51A gene was sequenced, and TR34/L98H mutation was identified.

Triazole resistance existing in Kenya calls for rational use of azole-based fungicides in agriculture over concerns of emerging antifungal resistance in clinical practice.

American Psychological Association (APA)

Kemoi, Edson K.& Nyerere, Andrew& Bii, Christine C.. 2018. Triazole-Resistant Aspergillus fumigatus from Fungicide-Experienced Soils in Naivasha Subcounty and Nairobi County, Kenya. International Journal of Microbiology،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1173379

Modern Language Association (MLA)

Kemoi, Edson K.…[et al.]. Triazole-Resistant Aspergillus fumigatus from Fungicide-Experienced Soils in Naivasha Subcounty and Nairobi County, Kenya. International Journal of Microbiology No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1173379

American Medical Association (AMA)

Kemoi, Edson K.& Nyerere, Andrew& Bii, Christine C.. Triazole-Resistant Aspergillus fumigatus from Fungicide-Experienced Soils in Naivasha Subcounty and Nairobi County, Kenya. International Journal of Microbiology. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1173379

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1173379