Myocardial Ischemia and Diabetes Mellitus: Role of Oxidative Stress in the Connection between Cardiac Metabolism and Coronary Blood Flow
Joint Authors
Fedele, Francesco
Mancone, Massimo
Severino, Paolo
Maestrini, Viviana
Netti, Lucrezia
D’Amato, Andrea
Infusino, Fabio
Pucci, Mariateresa
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-04
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Ischemic heart disease (IHD) has several risk factors, among which diabetes mellitus represents one of the most important.
In diabetic patients, the pathophysiology of myocardial ischemia remains unclear yet: some have atherosclerotic plaque which obstructs coronary blood flow, others show myocardial ischemia due to coronary microvascular dysfunction in the absence of plaques in epicardial vessels.
In the cross-talk between myocardial metabolism and coronary blood flow (CBF), ion channels have a main role, and, in diabetic patients, they are involved in the pathophysiology of IHD.
The exposition to the different cardiovascular risk factors and the ischemic condition determine an imbalance of the redox state, defined as oxidative stress, which shows itself with oxidant accumulation and antioxidant deficiency.
In particular, several products of myocardial metabolism, belonging to oxidative stress, may influence ion channel function, altering their capacity to modulate CBF, in response to myocardial metabolism, and predisposing to myocardial ischemia.
For this reason, considering the role of oxidative and ion channels in the pathophysiology of myocardial ischemia, it is allowed to consider new therapeutic perspectives in the treatment of IHD.
American Psychological Association (APA)
Severino, Paolo& D’Amato, Andrea& Netti, Lucrezia& Pucci, Mariateresa& Infusino, Fabio& Maestrini, Viviana…[et al.]. 2019. Myocardial Ischemia and Diabetes Mellitus: Role of Oxidative Stress in the Connection between Cardiac Metabolism and Coronary Blood Flow. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1173414
Modern Language Association (MLA)
Severino, Paolo…[et al.]. Myocardial Ischemia and Diabetes Mellitus: Role of Oxidative Stress in the Connection between Cardiac Metabolism and Coronary Blood Flow. Journal of Diabetes Research No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1173414
American Medical Association (AMA)
Severino, Paolo& D’Amato, Andrea& Netti, Lucrezia& Pucci, Mariateresa& Infusino, Fabio& Maestrini, Viviana…[et al.]. Myocardial Ischemia and Diabetes Mellitus: Role of Oxidative Stress in the Connection between Cardiac Metabolism and Coronary Blood Flow. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1173414
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173414