Effects of BSF on Podocyte Apoptosis via Regulating the ROS-Mediated PI3KAKT Pathway in DN
Joint Authors
Cui, Fangqiang
Gao, Yanbin
Zhao, Wenjing
Meng, Yuan
Shen, Cun
Liu, Zhi-qiang
Wang, Yue-Fen
Cai, Zhen
Jiang, Xin-can
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD).
The ROS-mediated PI3K/AKT pathway plays a key role in podocyte apoptosis and DN progression.
Our previous study demonstrated that Baoshenfang (BSF) can decrease proteinuria and attenuate podocyte injury.
However, the effects of BSF on podocyte apoptosis induced by the ROS-mediated PI3K/AKT pathway remain unclear.
Herein, in vivo and in vitro studies have been performed.
In our in vivo study, BSF significantly decreased 24-h urinary protein, serum creatinine, and blood urea nitrogen levels in DN mice.
Meanwhile, BSF significantly inhibited oxidative stress and podocyte apoptosis in our in vivo and in vitro studies.
Moreover, BSF significantly decreased the inhibition of the PI3K/AKT pathway induced by HG in DN.
More importantly, the effects of BSF on podocyte apoptosis were reversed by PI3K siRNA transfection.
In conclusion, BSF can decrease proteinuria and podocyte apoptosis in DN, in part through regulating the ROS-mediated PI3K/AKT pathway.
American Psychological Association (APA)
Cui, Fangqiang& Wang, Yue-Fen& Gao, Yanbin& Meng, Yuan& Cai, Zhen& Shen, Cun…[et al.]. 2019. Effects of BSF on Podocyte Apoptosis via Regulating the ROS-Mediated PI3KAKT Pathway in DN. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1173420
Modern Language Association (MLA)
Cui, Fangqiang…[et al.]. Effects of BSF on Podocyte Apoptosis via Regulating the ROS-Mediated PI3KAKT Pathway in DN. Journal of Diabetes Research No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1173420
American Medical Association (AMA)
Cui, Fangqiang& Wang, Yue-Fen& Gao, Yanbin& Meng, Yuan& Cai, Zhen& Shen, Cun…[et al.]. Effects of BSF on Podocyte Apoptosis via Regulating the ROS-Mediated PI3KAKT Pathway in DN. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1173420
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173420