The Adverse Effects of Thyrotropin Absence on Pancreatic β Cell Function in Mice
Joint Authors
Xiao, Wei
Liu, Chao
Chen, Jie
Yang, Yu
Zhang, Danyu
Wang, Kun
Mao, Xiaodong
Li, Xingjia
Chen, Yu
Wang, Jianhua
Ma, Xianghua
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Thyrotropin (TSH) is a modulator of glucose metabolism by binding to its receptor on pancreatic cells.
We used thyrotropin receptor (TSHR) knockout mice (Tshr-/-) as a model of TSH deletion to study its function in pancreatic β cells.
Tshr-/- mice had a similar body weight at birth compared with Tshr+/+ mice, but grew at a significantly slower rate until adulthood with adequate thyroxine supplementation.
TSH deletion led to lower fasting and postprandial blood glucose, insulin secretion impairment, and atrophy of islets in adult mice.
Transcription factors and markers of pancreatic β cell maturation, Pdx1, Nkx6.1, Glut2, and insulin, together with cell proliferation marker Ki67 showed no differences at the mRNA level between the two groups.
However, the Bax/Bcl-2 ratio was remarkably elevated in Tshr-/- mice at both mRNA and protein levels.
We hypothesized that pancreatic cell apoptosis, rather than abnormal cell proliferation and maturation, is associated with pancreatic dysfunction and glucose intolerance in the absence of TSH modulation.
American Psychological Association (APA)
Yang, Yu& Chen, Yu& Chen, Jie& Zhang, Danyu& Wang, Jianhua& Mao, Xiaodong…[et al.]. 2019. The Adverse Effects of Thyrotropin Absence on Pancreatic β Cell Function in Mice. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1173425
Modern Language Association (MLA)
Yang, Yu…[et al.]. The Adverse Effects of Thyrotropin Absence on Pancreatic β Cell Function in Mice. Journal of Diabetes Research No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1173425
American Medical Association (AMA)
Yang, Yu& Chen, Yu& Chen, Jie& Zhang, Danyu& Wang, Jianhua& Mao, Xiaodong…[et al.]. The Adverse Effects of Thyrotropin Absence on Pancreatic β Cell Function in Mice. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1173425
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173425