Frequency of Gestational Diabetes Mellitus Reappearance or Absence during the Second Pregnancy of Women Treated at Mayo Clinic between 2013 and 2018
Joint Authors
Sarras, Michael Peter
Ruano, Rodrigo
Egan, Aoife M.
Enninga, Elizabeth Ann L.
Leontovich, Alexey A.
Alrahmani, Layan
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The Center for Disease Control and Prevention ranks diabetes mellitus (DM) as the seventh leading cause of death in the USA.
The most prevalent forms of DM include Type 2 DM, Type 1 DM, and gestational diabetes mellitus (GDM).
While the acute problem of diabetic hyperglycemia can be clinically managed through dietary control and lifestyle changes or pharmacological intervention with oral medications or insulin, long-term complications of the disease are associated with significant morbidity and mortality.
These long-term complications involve nearly all organ systems of the body and share common pathologies associated with endothelial cell abnormalities.
To better understand the molecular mechanisms underlying DM as related to future long-term complications following hyperglycemia, we have undertaken a study to determine the frequency that GDM did or did not occur in the second pregnancy of women who experienced GDM in their first pregnancy between 2013 and 2018 at Mayo Clinic, Rochester, MN.
Within the five-year period of the study, the results indicate that 7,330 women received obstetrical care for pregnancy during the study period.
Of these, 150 developed GDM in their first pregnancy and of these, 42 (28%) had a second pregnancy.
Of these 42 women, 20 again developed GDM and 22 did not develop GDM in their second pregnancy within the study period.
Following the occurrence of GDM in the first pregnancy, the study (1) established the number of women with and without GDM in the second pregnancy and (2) confirmed the feasibility to study diabetic metabolic memory using maternal placental tissue from GDM women.
These studies represent Phase I of a larger research project whose goal is to analyze epigenetic mechanisms underlying true diabetic metabolic memory using endothelial cells isolated from the maternal placenta of women with and without GDM as described in this article.
American Psychological Association (APA)
Enninga, Elizabeth Ann L.& Egan, Aoife M.& Alrahmani, Layan& Leontovich, Alexey A.& Ruano, Rodrigo& Sarras, Michael Peter. 2019. Frequency of Gestational Diabetes Mellitus Reappearance or Absence during the Second Pregnancy of Women Treated at Mayo Clinic between 2013 and 2018. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1173462
Modern Language Association (MLA)
Enninga, Elizabeth Ann L.…[et al.]. Frequency of Gestational Diabetes Mellitus Reappearance or Absence during the Second Pregnancy of Women Treated at Mayo Clinic between 2013 and 2018. Journal of Diabetes Research No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1173462
American Medical Association (AMA)
Enninga, Elizabeth Ann L.& Egan, Aoife M.& Alrahmani, Layan& Leontovich, Alexey A.& Ruano, Rodrigo& Sarras, Michael Peter. Frequency of Gestational Diabetes Mellitus Reappearance or Absence during the Second Pregnancy of Women Treated at Mayo Clinic between 2013 and 2018. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1173462
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173462