Notoginsenoside Fc Accelerates Reendothelialization following Vascular Injury in Diabetic Rats by Promoting Endothelial Cell Autophagy
Joint Authors
Liu, Jingjing
Jiang, Chunyu
Ma, Xu
Feng, Lishuai
Wang, Jianbo
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-03
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Interventional therapies, such as percutaneous transluminal angioplasty and endovascular stent implantation, are used widely for the treatment of diabetic peripheral vascular complications.
Reendothelialization is an essential process in vascular injury following interventional therapy, and hyperglycemia in diabetes mellitus (DM) plays an important role in damaging endothelial layer integrity, leading to the retardance of reendothelialization and excessive neointimal formation.
Notoginsenoside Fc (Fc), a novel saponin isolated from Panax notoginseng, effectively counteracts platelet aggregation.
Nevertheless, the potential effects and molecular mechanisms of Fc on reendothelialization have yet to be explored.
In this study, we present novel findings that show the benefit of Fc in accelerating reendothelialization and alleviating excessive neointimal formation following carotid artery injury in diabetic Sprague–Dawley rats in vivo.
Simultaneously, the decreased autophagy of the injured carotid artery in diabetic rats was restored by Fc treatment.
Our in vitro results also demonstrated that Fc promoted endothelial cell proliferation and migration under high-glucose treatment by increasing autophagy.
In summary, this study supported the notion that Fc could accelerate reendothelialization following vascular injury in diabetic rats by promoting autophagy, suggesting that Fc may exert therapeutic benefits for early endothelial injury and restenosis following intervention in diabetes-associated vascular diseases.
American Psychological Association (APA)
Liu, Jingjing& Jiang, Chunyu& Ma, Xu& Feng, Lishuai& Wang, Jianbo. 2019. Notoginsenoside Fc Accelerates Reendothelialization following Vascular Injury in Diabetic Rats by Promoting Endothelial Cell Autophagy. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1173469
Modern Language Association (MLA)
Liu, Jingjing…[et al.]. Notoginsenoside Fc Accelerates Reendothelialization following Vascular Injury in Diabetic Rats by Promoting Endothelial Cell Autophagy. Journal of Diabetes Research No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1173469
American Medical Association (AMA)
Liu, Jingjing& Jiang, Chunyu& Ma, Xu& Feng, Lishuai& Wang, Jianbo. Notoginsenoside Fc Accelerates Reendothelialization following Vascular Injury in Diabetic Rats by Promoting Endothelial Cell Autophagy. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1173469
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173469