High Clostridium difficile Infection among HIV-Infected Children with Diarrhea in a Tertiary Hospital in Mwanza, Tanzania
Joint Authors
Mirambo, Mariam M.
Kabyemera, Rogatus
Silago, Vitus
Seugendo, Mwanaisha
Hokororo, Aldofine
Msanga, Delfina R.
Mshana, Stephen E.
Groß, Uwe
Source
International Journal of Pediatrics
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Clostridium difficile causes a million of illnesses each year worldwide and can affect people of all ages.
Limited data exist on the prevalence of C.
difficile infections (CDI) among children below five years of age in developing countries.
This study is aimed at determining the prevalence, associated factors, and outcome of the Clostridium difficile infection among children with diarrhea attending a tertiary hospital in Mwanza, Tanzania.
Stool samples were collected and cultured anaerobically to isolate Clostridium difficile, followed by C.
difficile toxin A and B assay and ribotyping.
A total of 301 children with diarrhea were enrolled.
A total of 22 (7.31%, 95% CI: 0.89-0.95) nonrepetitive stool samples were positive for Clostridium difficile.
Eighteen (81%) of C.
difficile isolates were toxigenic, and 16 (72.7%) had unknown ribotypes.
Independent predictors of positive C.
difficile were as follows: positive HIV status, hospital stay of more than four days, high stool leukocyte count, and watery stool.
Clostridium difficile-positive children had significantly higher median duration of the diarrhea than those without C.
difficile.
Clinicians should consider C.
difficile as a possible cause of diarrhea in children living in developing countries and institute appropriate management to prevent associated morbidities and mortalities.
Furthermore, there is a need of joint effort to improve C.
difficile diagnosis and surveillance in developing countries to establish the unknown epidemiology of CDI in these countries.
American Psychological Association (APA)
Seugendo, Mwanaisha& Hokororo, Aldofine& Kabyemera, Rogatus& Msanga, Delfina R.& Mirambo, Mariam M.& Silago, Vitus…[et al.]. 2020. High Clostridium difficile Infection among HIV-Infected Children with Diarrhea in a Tertiary Hospital in Mwanza, Tanzania. International Journal of Pediatrics،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1173561
Modern Language Association (MLA)
Seugendo, Mwanaisha…[et al.]. High Clostridium difficile Infection among HIV-Infected Children with Diarrhea in a Tertiary Hospital in Mwanza, Tanzania. International Journal of Pediatrics No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1173561
American Medical Association (AMA)
Seugendo, Mwanaisha& Hokororo, Aldofine& Kabyemera, Rogatus& Msanga, Delfina R.& Mirambo, Mariam M.& Silago, Vitus…[et al.]. High Clostridium difficile Infection among HIV-Infected Children with Diarrhea in a Tertiary Hospital in Mwanza, Tanzania. International Journal of Pediatrics. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1173561
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173561