Estimating Renal Function in the Elderly Malaysian Patients Attending Medical Outpatient Clinic: A Comparison between Creatinine Based and Cystatin-C Based Equations
Joint Authors
Jalalonmuhali, Maisarah
Kok Peng, Ng
Elagel, Salma Mohamed Abouzriba
Tan, Maw Pin
Lim, Soo Kun
Source
International Journal of Nephrology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
To assess the performance of different GFR estimating equations, test the diagnostic value of serum cystatin-C, and compare the applicability of cystatin-C based equation with serum creatinine based equation for estimating GFR (eGFR) in comparison with measured GFR in the elderly Malaysian patients.
Methods.
A cross-sectional study recruiting volunteered patients 65 years and older attending medical outpatient clinic.
51 chromium EDTA (51Cr-EDTA) was used as measured GFR.
The predictive capabilities of Cockcroft-Gault equation corrected for body surface area (CGBSA), four-variable Modification of Diet in Renal Disease (4-MDRD), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations using serum creatinine (CKD-EPIcr) as well as serum cystatin-C (CKD-EPIcys) were calculated.
Results.
A total of 40 patients, 77.5% male, with mean measured GFR 41.2±18.9 ml/min/1.73 m2 were enrolled.
Mean bias was the smallest for 4-MDRD; meanwhile, CKD-EPIcr had the highest precision and accuracy with lower limit of agreement among other equations.
CKD-EPIcys equation did not show any improvement in GFR estimation in comparison to CKD-EPIcr and MDRD.
Conclusion.
The CKD-EPIcr formula appears to be more accurate and correlates better with measured GFR in this cohort of elderly patients.
American Psychological Association (APA)
Jalalonmuhali, Maisarah& Elagel, Salma Mohamed Abouzriba& Tan, Maw Pin& Lim, Soo Kun& Kok Peng, Ng. 2018. Estimating Renal Function in the Elderly Malaysian Patients Attending Medical Outpatient Clinic: A Comparison between Creatinine Based and Cystatin-C Based Equations. International Journal of Nephrology،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1173600
Modern Language Association (MLA)
Jalalonmuhali, Maisarah…[et al.]. Estimating Renal Function in the Elderly Malaysian Patients Attending Medical Outpatient Clinic: A Comparison between Creatinine Based and Cystatin-C Based Equations. International Journal of Nephrology No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1173600
American Medical Association (AMA)
Jalalonmuhali, Maisarah& Elagel, Salma Mohamed Abouzriba& Tan, Maw Pin& Lim, Soo Kun& Kok Peng, Ng. Estimating Renal Function in the Elderly Malaysian Patients Attending Medical Outpatient Clinic: A Comparison between Creatinine Based and Cystatin-C Based Equations. International Journal of Nephrology. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1173600
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173600