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Prevalence of Neonatal Sepsis in Ethiopia: A Systematic Review and Meta-Analysis
Joint Authors
Assemie, Moges Agazhe
Alene, Muluneh
Yismaw, Lieltwork
Ketema, Daniel Bekele
Lamore, Yonas
Petrucka, Pammla
Alemu, Simegn
Source
International Journal of Pediatrics
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Introduction.
Neonatal sepsis is a systemic infection occurring in infants during the first 4 weeks of life and is a major cause of mortality and morbidities of newborns due to their age-related weak and immature immune systems.
In Ethiopia, despite many studies being conducted on neonatal sepsis, the reported findings are inconsistent.
The aim of this study is to determine the prevalence of neonatal sepsis to enhance the utility and interpretation of the evidence.
Methods.
An extensive systematic review and meta-analysis were performed to extract studies on the prevalence of neonatal sepsis in Ethiopia.
The PubMed, Cochrane Library, ScienceDirect, Web of Science, and Google Scholar were systematically searched.
Two independent authors selected and extracted the data from each included article.
The heterogeneity of included studies was assessed using the Higgins I2 test, and a random-effects model was performed in Stata/se Version 14.
Results.
Eighteen studies with a sample size of 10,495 study subjects were included with a reported range of neonatal sepsis from 17% to 78%.
The pooled prevalence of neonatal sepsis was 45% (95% CI: 35, 55; I2=99.3%, p<0.01).
Early onset neonatal sepsis was found to have a prevalence of 75.4% (95% CI: 68.3, 82.6).
Subgroup analysis in the study area (i.e., by region) was calculated revealing the highest neonatal sepsis in Amhara region at 64.4% (95% CI: 44.9, 84.0) and the lowest in Southern Nations, Nationality, and People at 28% (95% CI: 16, 40).
Conclusion.
In this review, the prevalence of neonatal sepsis in Ethiopia was found to be high, especially in terms of early onset neonatal sepsis.
As a result of the findings, it is important to consider the early and optimal points for interventions to better manage the prevalence and outcomes of neonatal sepsis.
Further research is needed to investigate the neonatal sepsis status at different regions and associated factors for neonatal sepsis not yet studied.
American Psychological Association (APA)
Assemie, Moges Agazhe& Alene, Muluneh& Yismaw, Lieltwork& Ketema, Daniel Bekele& Lamore, Yonas& Petrucka, Pammla…[et al.]. 2020. Prevalence of Neonatal Sepsis in Ethiopia: A Systematic Review and Meta-Analysis. International Journal of Pediatrics،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1173641
Modern Language Association (MLA)
Assemie, Moges Agazhe…[et al.]. Prevalence of Neonatal Sepsis in Ethiopia: A Systematic Review and Meta-Analysis. International Journal of Pediatrics No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1173641
American Medical Association (AMA)
Assemie, Moges Agazhe& Alene, Muluneh& Yismaw, Lieltwork& Ketema, Daniel Bekele& Lamore, Yonas& Petrucka, Pammla…[et al.]. Prevalence of Neonatal Sepsis in Ethiopia: A Systematic Review and Meta-Analysis. International Journal of Pediatrics. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1173641
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173641