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Phosphate, Calcification in Blood, and Mineral Stress: The Physiologic Blood Mineral Buffering System and Its Association with Cardiovascular Risk
Joint Authors
Pasch, Andreas
Smith, Edward R.
Jahnen-Dechent, Wilhelm
Source
International Journal of Nephrology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-02
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Phosphate is an important cardiovascular risk factor and lowering elevated blood phosphate concentrations is a main therapeutic target in kidney patients.
Phosphate is subject to the blood mineral buffering system which controls the precipitation of calcium and phosphate.
Calciprotein particles (CPP), self-assembling complexes of calcium phosphate and serum proteins, are the nanomorphological correlates of this system.
CPP1 are spherical, 50-100 nm in diameter, and contain amorphous mineral.
CPP2 are oblongated, 100-200nm in the long axis, and they contain a crystalline mineral core.
The relative abundance and biological activity of these particles are a matter of intense research, because they can cause oxidative stress, inflammation, and calcification in cellular assay.
Therapeutically reducing this endogenous stressor by prolonging crystal formation time might improve patient outcome.
This concise review article summarizes our current knowledge about the blood mineral buffering system and proposes Mineral Stress as a novel modifiable cardiovascular risk factor.
It furthermore outlines possible implications this might have for improving patient care.
American Psychological Association (APA)
Pasch, Andreas& Jahnen-Dechent, Wilhelm& Smith, Edward R.. 2018. Phosphate, Calcification in Blood, and Mineral Stress: The Physiologic Blood Mineral Buffering System and Its Association with Cardiovascular Risk. International Journal of Nephrology،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1173681
Modern Language Association (MLA)
Pasch, Andreas…[et al.]. Phosphate, Calcification in Blood, and Mineral Stress: The Physiologic Blood Mineral Buffering System and Its Association with Cardiovascular Risk. International Journal of Nephrology No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1173681
American Medical Association (AMA)
Pasch, Andreas& Jahnen-Dechent, Wilhelm& Smith, Edward R.. Phosphate, Calcification in Blood, and Mineral Stress: The Physiologic Blood Mineral Buffering System and Its Association with Cardiovascular Risk. International Journal of Nephrology. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1173681
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173681