Molecular Mechanisms Underlying Accelerated Aging by Defects in the FGF23-Klotho System
Author
Source
International Journal of Nephrology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The basic research of aging has been primarily focused on elucidating mechanisms of aging and longevity that are evolutionarily conserved from yeasts to primates.
Such efforts have culminated in the notion that (1) senescence at the cellular level is associated with aging at the organismal level and that (2) calorie restriction and growth suppression decelerate aging.
However, these important findings in the basic research have not necessarily been linked to improvement of daily medical practice in the aging society.
It has become increasingly important to investigate mechanisms of aging unique to mammals or humans and apply the research fruits for the treatment of major age-related disorders to extend the health span.
Seminal studies on the klotho mouse, a mutant exhibiting a premature aging syndrome, have identified phosphate as a proaging factor in mammals.
In this review, mechanisms of phosphate-induced premature aging and potential therapeutic targets will be discussed, which may be directly applicable for developing novel strategies for the treatment of chronic kidney disease and its complications.
American Psychological Association (APA)
Kuro-o, Makoto. 2018. Molecular Mechanisms Underlying Accelerated Aging by Defects in the FGF23-Klotho System. International Journal of Nephrology،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1173689
Modern Language Association (MLA)
Kuro-o, Makoto. Molecular Mechanisms Underlying Accelerated Aging by Defects in the FGF23-Klotho System. International Journal of Nephrology No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1173689
American Medical Association (AMA)
Kuro-o, Makoto. Molecular Mechanisms Underlying Accelerated Aging by Defects in the FGF23-Klotho System. International Journal of Nephrology. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1173689
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173689