Effectual Anticancer Potentiality of Loaded Bee Venom onto Fungal Chitosan Nanoparticles
Joint Authors
El Rabey, Haddad A.
Alalawy, Adel I.
Almutairi, Fahad M.
Tayel, Ahmed A.
Al-Duais, Mohammed A.
Zidan, Nahla S.
Sakran, Mohamed I.
Source
International Journal of Polymer Science
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Chitosan and its nanoparticles (NPs) could be extracted from numerous fungal species and used as effectual carriers for bioactive compounds.
The fungal chitosan (FC) was innovatively acquired from Fusarium oxysporum grown mycelia, characterized and used for NP synthesis and loading with bee venom (BV).
The nano-FC (NFC) had 192.4 nm mean NP diameter, 38.22% loading capacity, and 92.42% entrapment efficiency.
BV release from NFC was pH and time dependent; burst BV release was detected at the first 6 h, followed by gradual releases up to 30 h.
The in vitro anticancer potentiality valuation, of NFC, BV, and NFC/BV nanoconjugates against HeLa cervix carcinoma, revealed that they all had potent dose-dependent anticancer activity; BV/NFC nanoconjugates were the most effective with IC50=200 μg/mL.
The fluorescent staining of treated HeLa cells with BV/NFC nanoconjugates, with DAPI and acridine orange/propidium iodide combination, indicated the appearance of early apoptosis, secondary apoptosis, and secondary necrosis markers and their increment with exposure prolongation.
The production of NFC from F.
oxysporum and their loading with BV are strongly counseled for production of potent natural antitumor agent with augmented activity against cervix carcinoma.
American Psychological Association (APA)
Alalawy, Adel I.& El Rabey, Haddad A.& Almutairi, Fahad M.& Tayel, Ahmed A.& Al-Duais, Mohammed A.& Zidan, Nahla S.…[et al.]. 2020. Effectual Anticancer Potentiality of Loaded Bee Venom onto Fungal Chitosan Nanoparticles. International Journal of Polymer Science،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1173741
Modern Language Association (MLA)
Alalawy, Adel I.…[et al.]. Effectual Anticancer Potentiality of Loaded Bee Venom onto Fungal Chitosan Nanoparticles. International Journal of Polymer Science No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1173741
American Medical Association (AMA)
Alalawy, Adel I.& El Rabey, Haddad A.& Almutairi, Fahad M.& Tayel, Ahmed A.& Al-Duais, Mohammed A.& Zidan, Nahla S.…[et al.]. Effectual Anticancer Potentiality of Loaded Bee Venom onto Fungal Chitosan Nanoparticles. International Journal of Polymer Science. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1173741
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173741