Characterization, Disintegration, and Dissolution Analyses of Carrageenan-Based Hard-Shell Capsules Cross-Linked with Maltodextrin as a Potential Alternative Drug Delivery System
Joint Authors
Fauzi, Muhammad Al Rizqi Dharma
Pudjiastuti, Pratiwi
Hendradi, Esti
Widodo, Riyanto Teguh
Amin, Mohd. Cairul Iqbal Mohd.
Source
International Journal of Polymer Science
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Hard-shell capsules commonly consist of gelatin which is not a universal material considering it is extracted from animal parts.
Moreover, the mad cow disease triggered the scrutinization of the use of gelatin in pharmaceutical products.
Hence, an alternative to conventional hard-shell capsules is needed.
Carrageenan- (CRG-) based hard-shell capsules were successfully prepared by cross-linking CRG with maltodextrin (MD) and plasticizing with sorbitol (SOR).
These CRG-MD/SOR hard-shell capsules were produced as an alternative to conventional hard-shell capsules in the oral drug delivery system (DDS).
The physical properties of CRG-MD/SOR capsules were characterized using the degree of swelling, FTIR, and SEM analyses.
The disintegration and dissolution profile release of paracetamol from CRG-MD/SOR hard-shell capsules was performed in an aqueous medium with three different pH levels.
The degree of swelling of CRG-MD/SOR was 529.23±128.10%.
The main peaks in the FTIR spectrum of CRG-MD/SOR were at 1248, 930, 847, and 805 cm−1 for ester sulfate groups, 3,6-anhydrogalactose, galactose-4-sulfate, and 3,6-anhydrogalactose-2-sulfate, respectively.
The SEM analysis exhibited minuscule pores on the surface of CRG and CRG-MD/SOR at 5000 times of magnification.
The CRG-MD/SOR capsules required 18.47±0.11 min on average to disintegrate.
The CRG-MD/SOR dissolution was better in a weakly acidic medium (pH 4.5) than in a strongly acidic (pH 1.2) and neutral (pH 6.8) media.
Based on the aforementioned results, CRG-MD/SOR capsules are the potential candidate to replace conventional hard-shell capsules.
American Psychological Association (APA)
Fauzi, Muhammad Al Rizqi Dharma& Pudjiastuti, Pratiwi& Hendradi, Esti& Widodo, Riyanto Teguh& Amin, Mohd. Cairul Iqbal Mohd.. 2020. Characterization, Disintegration, and Dissolution Analyses of Carrageenan-Based Hard-Shell Capsules Cross-Linked with Maltodextrin as a Potential Alternative Drug Delivery System. International Journal of Polymer Science،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1173752
Modern Language Association (MLA)
Fauzi, Muhammad Al Rizqi Dharma…[et al.]. Characterization, Disintegration, and Dissolution Analyses of Carrageenan-Based Hard-Shell Capsules Cross-Linked with Maltodextrin as a Potential Alternative Drug Delivery System. International Journal of Polymer Science No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1173752
American Medical Association (AMA)
Fauzi, Muhammad Al Rizqi Dharma& Pudjiastuti, Pratiwi& Hendradi, Esti& Widodo, Riyanto Teguh& Amin, Mohd. Cairul Iqbal Mohd.. Characterization, Disintegration, and Dissolution Analyses of Carrageenan-Based Hard-Shell Capsules Cross-Linked with Maltodextrin as a Potential Alternative Drug Delivery System. International Journal of Polymer Science. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1173752
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173752