Natriuretic Peptide System Activation in Acute Heart Failure Patients with Diabetes
Joint Authors
Cunha, F. M.
Lourenço, P.
Bettencourt, P.
Moreira, Helena
Pereira, Joana
Marques, Pedro
Rodrigues, Pedro
Pinto, Maria João
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-02
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Elevated B-type natriuretic peptide (BNP) is a hallmark in heart failure (HF).
Diabetic patients with chronic HF seem to have higher BNP than nondiabetics.
We studied, in acute HF, if BNP levels are different between diabetics and nondiabetics.
Methods.
From a prospectively recruited population of acute HF patients, we selected a convenience sample.
In pair-matched analysis, each diabetic patient was matched with a nondiabetic of the same age (±1 year), gender, and according to left ventricular systolic dysfunction.
Diabetics and nondiabetics were compared.
Cox-regression analysis was used to analyse the prognostic impact of diabetes.
Results.
We studied 328 patients, mean age: 78 years, 44.5% male.
Diabetics were more often hypertensive and had ischemic HF; they had higher body mass index, lower haemoglobin, and worse renal function.
Diabetics were more often discharged on ACE inhibitors/ARB, antiplatelet therapy, and statins.
Neither admission nor discharge BNP values differed between diabetics and pair-matched nondiabetics.
One-year mortality was also nondifferent between pairs of diabetics and nondiabetics: 44 (26.8%) and 46 (28.0%), respectively.
HR for 1-year mortality in diabetics was 1.00 (95% CI: 0.82–1.24) compared with nondiabetics.
Conclusions.
HF patients with diabetes have similar neurohumoral activation when compared with nondiabetics.
One-year mortality is also nondifferent after matching for age, gender, and systolic function.
American Psychological Association (APA)
Cunha, F. M.& Pereira, Joana& Marques, Pedro& Moreira, Helena& Rodrigues, Pedro& Pinto, Maria João…[et al.]. 2017. Natriuretic Peptide System Activation in Acute Heart Failure Patients with Diabetes. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1173759
Modern Language Association (MLA)
Cunha, F. M.…[et al.]. Natriuretic Peptide System Activation in Acute Heart Failure Patients with Diabetes. Journal of Diabetes Research No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1173759
American Medical Association (AMA)
Cunha, F. M.& Pereira, Joana& Marques, Pedro& Moreira, Helena& Rodrigues, Pedro& Pinto, Maria João…[et al.]. Natriuretic Peptide System Activation in Acute Heart Failure Patients with Diabetes. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1173759
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173759