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Angularly Resolved Deep Brain Fluorescence Imaging Using a Single Optical Fiber
Joint Authors
Helmstetter, Fred J.
De La Rosa, Israel Jacob
Pashaie, Ramin
Azimipour, Mehdi
Cullen, Patrick K.
Source
International Journal of Optics
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
In this article, we report the development of a minimally invasive fiber optic based fluorescence probe which can reach deep brain objects and measure the intensity and spatial distribution of fluorescence signals in the tissue.
In this design, the brain is scanned by a single penetrating side-firing optical fiber which delivers excitation light pulses to the tissue at different depths and orientations and simultaneously collects samples of fluorescence emission signals.
Signal-to-noise ratio of the measurements is improved by adapting the pulse compression technique and the theory of optimal filters.
Effects of each design parameter on the overall performance of the scanner, including the spatial resolution and speed of scanning, are analyzed and experimentally measured.
In vivo experiments show that the new device, despite the simplicity of the design, provides valuable information particularly useful in optogenetic stimulation experiments where the exact position of the fiber tip and the radiation orientation can change the outcome of a test.
American Psychological Association (APA)
De La Rosa, Israel Jacob& Azimipour, Mehdi& Cullen, Patrick K.& Helmstetter, Fred J.& Pashaie, Ramin. 2018. Angularly Resolved Deep Brain Fluorescence Imaging Using a Single Optical Fiber. International Journal of Optics،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1173777
Modern Language Association (MLA)
De La Rosa, Israel Jacob…[et al.]. Angularly Resolved Deep Brain Fluorescence Imaging Using a Single Optical Fiber. International Journal of Optics No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1173777
American Medical Association (AMA)
De La Rosa, Israel Jacob& Azimipour, Mehdi& Cullen, Patrick K.& Helmstetter, Fred J.& Pashaie, Ramin. Angularly Resolved Deep Brain Fluorescence Imaging Using a Single Optical Fiber. International Journal of Optics. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1173777
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173777