Paediatric Autoimmune Neuropsychiatric Disorder Associated with Group A Beta-Haemolytic Streptococcal Infection: An Indication for Tonsillectomy? A Review of the Literature
Joint Authors
Rajgor, Amarkumar Dhirajlal
Hakim, Navid Akhtar
Ali, Sanah
Darr, Adnan
Source
International Journal of Otolaryngology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Paediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection (PANDAS) is the acute onset of neuropsychiatric symptoms following group A beta-haemolytic streptococcal infection.
The aetiology remains elusive.
However, with group A streptococcus being the most common bacterial cause of tonsillitis, surgical intervention in the form of tonsillectomy has often been considered as a potential therapy.
Methods.
A MEDLINE® search was undertaken using keywords “PANDAS” or “paediatric autoimmune neuropsychiatric disorders associated with streptococcus” combined with “tonsillectomy”.
Results.
Six case reports and 3 case series met the inclusion criteria.
Demesh et al.
(case series) reported a dramatic reduction in neuropsychiatric symptom severity in the patient cohort undergoing tonsillectomy.
Two case series suggest that there is no association between tonsillectomy and resolution of PANDAS.
Conclusion.
Due to the lack of uniform data and sporadic reports, tonsillectomy should be carefully adopted for the treatment of this disorder.
In particular, tonsillectomies/adenoidectomies to alleviate neuropsychiatric symptoms should be avoided until more definitive evidence is at our disposal.
This review highlights the importance of a potential collaborative prospective study.
American Psychological Association (APA)
Rajgor, Amarkumar Dhirajlal& Hakim, Navid Akhtar& Ali, Sanah& Darr, Adnan. 2018. Paediatric Autoimmune Neuropsychiatric Disorder Associated with Group A Beta-Haemolytic Streptococcal Infection: An Indication for Tonsillectomy? A Review of the Literature. International Journal of Otolaryngology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1173814
Modern Language Association (MLA)
Rajgor, Amarkumar Dhirajlal…[et al.]. Paediatric Autoimmune Neuropsychiatric Disorder Associated with Group A Beta-Haemolytic Streptococcal Infection: An Indication for Tonsillectomy? A Review of the Literature. International Journal of Otolaryngology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1173814
American Medical Association (AMA)
Rajgor, Amarkumar Dhirajlal& Hakim, Navid Akhtar& Ali, Sanah& Darr, Adnan. Paediatric Autoimmune Neuropsychiatric Disorder Associated with Group A Beta-Haemolytic Streptococcal Infection: An Indication for Tonsillectomy? A Review of the Literature. International Journal of Otolaryngology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1173814
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173814