Relationships between Composition of Major Fatty Acids and Fat Distribution and Insulin Resistance in Japanese
Joint Authors
Meguro, Shu
Itoh, Hiroshi
Fujii, Chikako
Azuma, Koichiro
Oguma, Yuko
Katsukawa, Fuminori
Tanaka, Kumiko
Matsumoto, Hideo
Hirose, Hiroshi
Kawai, Toshihide
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
The aim of this study was to evaluate the relationships between the composition of free fatty acids (FFAs) and metabolic parameters, including body fat distribution, in Japanese.
Methods.
The study subjects were 111 Japanese patients (54 males, 57 females).
Metabolic parameters and visceral and subcutaneous fat areas as determined by CT scanning at the umbilical level were measured.
Glucose tolerance test (GTT) was performed by administering 75 g glucose orally.
Results.
The percentage of linoleic acid (C18:2), the greatest constituent among FFAs, was negatively correlated with visceral fat area (r=−0.411, p<0.0001), fasting glucose (r=−0.330, p<0.0001), HbA1c (r=−0.231, p=0.0146), and systolic blood pressure (r=−0.224, p=0.0184).
Linoleic acid percentage was also significantly negatively correlated with HOMA-IR (r=−0.416, p<0.0001) by simple correlation.
Based on the findings of OGTT, the 111 subjects were classified into three groups: 33 with normal glucose tolerance, 71 with impaired glucose tolerance (IGT), and 7 diabetic subjects.
The percentage of serum linoleic acid in diabetic subjects was significantly lower than that in normal subjects.
Conclusion.
We conclude that serum linoleic acid level is negatively correlated with the accumulation of visceral fat in relation to a reduction of insulin resistance in Japanese subjects.
American Psychological Association (APA)
Fujii, Chikako& Kawai, Toshihide& Azuma, Koichiro& Oguma, Yuko& Katsukawa, Fuminori& Hirose, Hiroshi…[et al.]. 2017. Relationships between Composition of Major Fatty Acids and Fat Distribution and Insulin Resistance in Japanese. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1173828
Modern Language Association (MLA)
Fujii, Chikako…[et al.]. Relationships between Composition of Major Fatty Acids and Fat Distribution and Insulin Resistance in Japanese. Journal of Diabetes Research No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1173828
American Medical Association (AMA)
Fujii, Chikako& Kawai, Toshihide& Azuma, Koichiro& Oguma, Yuko& Katsukawa, Fuminori& Hirose, Hiroshi…[et al.]. Relationships between Composition of Major Fatty Acids and Fat Distribution and Insulin Resistance in Japanese. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1173828
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173828