The Role of Oxidative Stress, Mitochondrial Function, and Autophagy in Diabetic Polyneuropathy

Joint Authors

Miranda-Díaz, Alejandra Guillermina
Sifuentes-Franco, Sonia
Rodríguez-Carrizalez, Adolfo Daniel
Pacheco Moisés, Fermín Paul

Source

Journal of Diabetes Research

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-15, 15 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-10-24

Country of Publication

Egypt

No. of Pages

15

Main Subjects

Diseases
Medicine

Abstract EN

Diabetic polyneuropathy (DPN) is the most frequent and prevalent chronic complication of diabetes mellitus (DM).

The state of persistent hyperglycemia leads to an increase in the production of cytosolic and mitochondrial reactive oxygen species (ROS) and favors deregulation of the antioxidant defenses that are capable of activating diverse metabolic pathways which trigger the presence of nitro-oxidative stress (NOS) and endoplasmic reticulum stress.

Hyperglycemia provokes the appearance of micro- and macrovascular complications and favors oxidative damage to the macromolecules (lipids, carbohydrates, and proteins) with an increase in products that damage the DNA.

Hyperglycemia produces mitochondrial dysfunction with deregulation between mitochondrial fission/fusion and regulatory factors.

Mitochondrial fission appears early in diabetic neuropathy with the ability to facilitate mitochondrial fragmentation.

Autophagy is a catabolic process induced by oxidative stress that involves the formation of vesicles by the lysosomes.

Autophagy protects cells from diverse stress factors and routine deterioration.

Clarification of the mechanisms involved in the appearance of complications in DM will facilitate the selection of specific therapeutic options based on the mechanisms involved in the metabolic pathways affected.

Nowadays, the antioxidant agents consumed exogenously form an adjuvant therapeutic alternative in chronic degenerative metabolic diseases, such as DM.

American Psychological Association (APA)

Sifuentes-Franco, Sonia& Pacheco Moisés, Fermín Paul& Rodríguez-Carrizalez, Adolfo Daniel& Miranda-Díaz, Alejandra Guillermina. 2017. The Role of Oxidative Stress, Mitochondrial Function, and Autophagy in Diabetic Polyneuropathy. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1173842

Modern Language Association (MLA)

Sifuentes-Franco, Sonia…[et al.]. The Role of Oxidative Stress, Mitochondrial Function, and Autophagy in Diabetic Polyneuropathy. Journal of Diabetes Research No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1173842

American Medical Association (AMA)

Sifuentes-Franco, Sonia& Pacheco Moisés, Fermín Paul& Rodríguez-Carrizalez, Adolfo Daniel& Miranda-Díaz, Alejandra Guillermina. The Role of Oxidative Stress, Mitochondrial Function, and Autophagy in Diabetic Polyneuropathy. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1173842

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1173842