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Spatiotemporal Regulators for Insulin-Stimulated GLUT4 Vesicle Exocytosis
Joint Authors
Xu, Yingke
Zhou, Xiaoxu
Shentu, Ping
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Insulin increases glucose uptake and storage in muscle and adipose cells, which is accomplished through the mobilization of intracellular GLUT4 storage vesicles (GSVs) to the cell surface upon stimulation.
Importantly, the dysfunction of insulin-regulated GLUT4 trafficking is strongly linked with peripheral insulin resistance and type 2 diabetes in human.
The insulin signaling pathway, key signaling molecules involved, and precise trafficking itinerary of GSVs are largely identified.
Understanding the interaction between insulin signaling molecules and key regulatory proteins that are involved in spatiotemporal regulation of GLUT4 vesicle exocytosis is of great importance to explain the pathogenesis of diabetes and may provide new potential therapeutic targets.
American Psychological Association (APA)
Zhou, Xiaoxu& Shentu, Ping& Xu, Yingke. 2017. Spatiotemporal Regulators for Insulin-Stimulated GLUT4 Vesicle Exocytosis. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1173844
Modern Language Association (MLA)
Zhou, Xiaoxu…[et al.]. Spatiotemporal Regulators for Insulin-Stimulated GLUT4 Vesicle Exocytosis. Journal of Diabetes Research No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1173844
American Medical Association (AMA)
Zhou, Xiaoxu& Shentu, Ping& Xu, Yingke. Spatiotemporal Regulators for Insulin-Stimulated GLUT4 Vesicle Exocytosis. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1173844
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173844