![](/images/graphics-bg.png)
Muscle Lipid Metabolism: Role of Lipid Droplets and Perilipins
Joint Authors
Morales, Pablo Esteban
Bucarey, Jose Luis
Espinosa, Alejandra
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Skeletal muscle is one of the main regulators of carbohydrate and lipid metabolism in our organism, and therefore, it is highly susceptible to changes in glucose and fatty acid (FA) availability.
Skeletal muscle is an extremely complex tissue: its metabolic capacity depends on the type of fibers it is made up of and the level of stimulation it undergoes, such as acute or chronic contraction.
Obesity is often associated with increased FA levels, which leads to the accumulation of toxic lipid intermediates, oxidative stress, and autophagy in skeletal fibers.
This lipotoxicity is one of the most common causes of insulin resistance (IR).
In this scenario, the “isolation” of certain lipids in specific cell compartments, through the action of the specific lipid droplet, perilipin (PLIN) family of proteins, is conceived as a lifeguard compensatory strategy.
In this review, we summarize the cellular mechanism underlying lipid mobilization and metabolism inside skeletal muscle, focusing on the function of lipid droplets, the PLIN family of proteins, and how these entities are modified in exercise, obesity, and IR conditions.
American Psychological Association (APA)
Morales, Pablo Esteban& Bucarey, Jose Luis& Espinosa, Alejandra. 2017. Muscle Lipid Metabolism: Role of Lipid Droplets and Perilipins. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1173856
Modern Language Association (MLA)
Morales, Pablo Esteban…[et al.]. Muscle Lipid Metabolism: Role of Lipid Droplets and Perilipins. Journal of Diabetes Research No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1173856
American Medical Association (AMA)
Morales, Pablo Esteban& Bucarey, Jose Luis& Espinosa, Alejandra. Muscle Lipid Metabolism: Role of Lipid Droplets and Perilipins. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1173856
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173856