Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy
Joint Authors
Liu, Bao-li
Dai, Haoran
Liu, Qingquan
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Diabetic nephropathy (DN) together with glomerular hyperfiltration has been implicated in the development of diabetic microangiopathy in the initial stage of diabetic diseases.
Increased amounts of urinary protein in DN may be associated with functional and morphological alterations of podocyte, mainly including podocyte hypertrophy, epithelial-mesenchymal transdifferentiation (EMT), podocyte detachment, and podocyte apoptosis.
Accumulating studies have revealed that disruption in multiple renal signaling pathways had been critical in the progression of these pathological damages, such as adenosine monophosphate-activated kinase signaling pathways (AMPK), wnt/β-catenin signaling pathways, endoplasmic reticulum stress-related signaling pathways, mammalian target of rapamycin (mTOR)/autophagy pathway, and Rho GTPases.
In this review, we highlight new molecular insights underlying podocyte injury in the progression of DN, which offer new therapeutic targets to develop important renoprotective treatments for DN over the next decade.
American Psychological Association (APA)
Dai, Haoran& Liu, Qingquan& Liu, Bao-li. 2017. Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1173930
Modern Language Association (MLA)
Dai, Haoran…[et al.]. Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy. Journal of Diabetes Research No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1173930
American Medical Association (AMA)
Dai, Haoran& Liu, Qingquan& Liu, Bao-li. Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1173930
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173930