Multicomponent Nanocomposites for Complex Anticancer Therapy: Effect of Aggregation Processes on Their Efficacy
Joint Authors
Chumachenko, V. A.
Kutsevol, N. V.
Harahuts, Iu
Bezugla, Tetiana
Chekhun, Vasyl
Source
International Journal of Polymer Science
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Multicomponent nanocomposites for anticancer therapy were prepared, characterized, and tested for their antitumor efficacy.
The water-soluble star-like dextran-graft-polyacrylamide copolymer was used as a nanoplatform for the creation of polymer-based multicomponent drug delivery systems for photodynamic and combined (photodynamic+chemotherapy) antitumor therapy.
The three-component nanocomposites with incorporated gold nanoparticles and photosensitizer and the four-component ones additionally loaded by Doxorubicin into polymer nanoplatform were studied at 25 and 37°C by transmission electron microscopy and dynamic light scattering.
Nanocomposites were tested for their photodynamic cytotoxicity for the cell line of breast cancer MCF-7/S.
Three-component nanocomposites demonstrated higher efficacy than the four-component ones.
The decrease in the activity of the four-component systems is explained by the aggregation process caused by the introduction of an additional component, which leads to a decrease in the hydrophilic-hydrophobic balance of the polymer macromolecule.
American Psychological Association (APA)
Kutsevol, N. V.& Harahuts, Iu& Bezugla, Tetiana& Chumachenko, V. A.& Chekhun, Vasyl. 2020. Multicomponent Nanocomposites for Complex Anticancer Therapy: Effect of Aggregation Processes on Their Efficacy. International Journal of Polymer Science،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1173939
Modern Language Association (MLA)
Kutsevol, N. V.…[et al.]. Multicomponent Nanocomposites for Complex Anticancer Therapy: Effect of Aggregation Processes on Their Efficacy. International Journal of Polymer Science No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1173939
American Medical Association (AMA)
Kutsevol, N. V.& Harahuts, Iu& Bezugla, Tetiana& Chumachenko, V. A.& Chekhun, Vasyl. Multicomponent Nanocomposites for Complex Anticancer Therapy: Effect of Aggregation Processes on Their Efficacy. International Journal of Polymer Science. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1173939
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173939