Antidiabetic Effect of Brain-Derived Neurotrophic Factor and Its Association with Inflammation in Type 2 Diabetes Mellitus
Joint Authors
Eyileten, Ceren
Kapłon-Cieślicka, Agnieszka
Mirowska-Guzel, Dagmara
Malek, Lukasz
Postula, Marek
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-14
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Brain-derived neurotrophic factor (BDNF) is a neurotrophin, which plays an important role in the central nervous system, and systemic or peripheral inflammatory conditions, such as acute coronary syndrome and type 2 diabetes mellitus (T2DM).
BDNF is also expressed in several nonneuronal tissues, and platelets are the major source of peripheral BDNF.
Here, we reviewed the potential role of BDNF in platelet reactivity in T2DM and its association with selected inflammatory and platelet activation mediators.
Besides that, we focused on adipocytokines such as leptin, resistin, and adiponectin which are considered to take part in inflammation and both lipid and glucose metabolism in diabetic patients as previous studies showed the relation between adipocytokines and BDNF.
We also reviewed the evidences of the antidiabetic effect of BDNF and the association with circulating inflammatory cytokines in T2DM.
American Psychological Association (APA)
Eyileten, Ceren& Kapłon-Cieślicka, Agnieszka& Mirowska-Guzel, Dagmara& Malek, Lukasz& Postula, Marek. 2017. Antidiabetic Effect of Brain-Derived Neurotrophic Factor and Its Association with Inflammation in Type 2 Diabetes Mellitus. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1173972
Modern Language Association (MLA)
Eyileten, Ceren…[et al.]. Antidiabetic Effect of Brain-Derived Neurotrophic Factor and Its Association with Inflammation in Type 2 Diabetes Mellitus. Journal of Diabetes Research No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1173972
American Medical Association (AMA)
Eyileten, Ceren& Kapłon-Cieślicka, Agnieszka& Mirowska-Guzel, Dagmara& Malek, Lukasz& Postula, Marek. Antidiabetic Effect of Brain-Derived Neurotrophic Factor and Its Association with Inflammation in Type 2 Diabetes Mellitus. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1173972
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173972