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Serum Peptidomic Profile as a Novel Biomarker for Rheumatoid Arthritis
Joint Authors
Abdelati, Abeer A.
Elnemr, Rehab A.
Kandil, Noha S.
Dwedar, Fatma I.
Ghazala, Rasha A.
Source
International Journal of Rheumatology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Over the last decades, there has been an increasing need to discover new diagnostic RA biomarkers, other than the current serologic biomarkers, which can assist early diagnosis and response to treatment.
The purpose of this study was to analyze the serum peptidomic profile in patients with rheumatoid arthritis (RA) by using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
The study included 35 patients with rheumatoid arthritis (RA), 35 patients with primary osteoarthritis (OA) as the disease control (DC), and 35 healthy controls (HC).
All participants were subjected to serum peptidomic profile analysis using magnetic bead (MB) separation (MALDI-TOF-MS).
The trial showed 113 peaks that discriminated RA from OA and 101 peaks that discriminated RA from HC.
Moreover, 95 peaks were identified and discriminated OA from HC; 38 were significant (p<0.05) and 57 nonsignificant.
The genetic algorithm (GA) model showed the best sensitivity and specificity in the three trials (RA versus HC, OA versus HC, and RA versus OA).
The present data suggested that the peptidomic pattern is of value for differentiating individuals with RA from OA and healthy controls.
We concluded that MALDI-TOF-MS combined with MB is an effective technique to identify novel serum protein biomarkers related to RA.
American Psychological Association (APA)
Abdelati, Abeer A.& Elnemr, Rehab A.& Kandil, Noha S.& Dwedar, Fatma I.& Ghazala, Rasha A.. 2020. Serum Peptidomic Profile as a Novel Biomarker for Rheumatoid Arthritis. International Journal of Rheumatology،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1173983
Modern Language Association (MLA)
Abdelati, Abeer A.…[et al.]. Serum Peptidomic Profile as a Novel Biomarker for Rheumatoid Arthritis. International Journal of Rheumatology No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1173983
American Medical Association (AMA)
Abdelati, Abeer A.& Elnemr, Rehab A.& Kandil, Noha S.& Dwedar, Fatma I.& Ghazala, Rasha A.. Serum Peptidomic Profile as a Novel Biomarker for Rheumatoid Arthritis. International Journal of Rheumatology. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1173983
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173983