Role of Secreted Frizzled-Related Protein 1 and Tumor Necrosis Factor-α (TNF-α)‎ in Bone Loss of Patients with Rheumatoid Arthritis

Abstract EN

Bone loss is one of the emerging extra-articular manifestations of rheumatoid arthritis.

TNF-α is the main inflammatory cytokine that can directly increase bone resorption.

However, its role in bone formation is still unknown, especially related to secreted frizzled-related protein 1 (SFRP-1), an osteoblast inhibitor.

This study examines the correlation between TNF-α and SFRP-1, with a bone turn over marker (CTX and P1NP).

This is a cross-sectional study with 38 subjects of premenopausal female patients with RA.

This study found that 60.6% of the patients were in remission or low disease activity.

The median of TNF-α was 10.6 pg/mL, mean of SFRP-1 was 9.29 ng/mL, mean of CTX was 2.74 ng/mL, and the median of P1NP was 34.04 pg/ml.

There is positive correlation between TNF-α and P1NP (r=0.363, p=0.026), also between SFRP-1 and P1NP (r=0.341; p=0.036).

A low level of TNF-?, high level of SFRP-1, high level of CTX, and low level of P1NP in this study indicate a high bone turn over process, with dominant resorption activity in premenopausal female patients with RA.