Are Stem Cells Derived from Synovium and Fat Pad Able to Treat Induced Knee Osteoarthritis in Rats?
Joint Authors
Koohi-Hosseinabadi, Omid
Bhimani, Rohan
Zare, Reza
Tanideh, Nader
Nikahval, Behrooz
Mirtalebi, Maryam Sadat
Ahmadi, Nasrollah
Zarea, Shahrokh
Ashkani-Esfahani, Soheil
Source
International Journal of Rheumatology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Osteoarthritis (OA) is a chronic disease and a significant cause of joint pain, tenderness, and limitation of motion.
At present, no specific treatment is available, and mesenchymal stem cells (MSCs) have shown promising potentials in this regard.
Herein, we aimed to evaluate the repairing potentials of stem cells derived from the synovium and fat pad in the treatment of OA.
Methods.
Twenty-eight male rats (220±20 g, aged 10-12 weeks), were randomly divided into four groups (n=7): C1: nontreated group, C2: Hyalgan-treated group, E1: adipose tissue-derived stem cell-treated group, and E2: synovial membrane-based stem cell-treated group.
Collagenase type II was injected into the left knee; after eight weeks, OA was developed.
Then, stem cells were injected, and rats were followed for three months.
Afterward, specimens and radiological images were investigated.
p value ≤ 0.05 was set as statistically significant.
Results.
Compared to the C1 group, the E1 and E2 groups showed significantly better results in all six pathological criteria as well as joint space width and osteophytes of medial tibial, medial femoral, and medial fabellar condyles (p≤0.001).
Similarly, compared to the C2 group, the E1 and E2 groups had better scores regarding surface, matrix, cell distribution, and cell population viability (p<0.05).
E2 showed considerably higher scores compared to C2 regarding subchondral bone and cartilage mineralization (p<0.05).
The joint space width was similar between the C2 and E groups.
Conclusion.
Treatment of OA with MSCs, particularly synovial membrane-derived stem cells, not only prevented but also healed OA of the knee to some extent in comparison to the Hyalgan and nontreatment groups.
American Psychological Association (APA)
Zare, Reza& Tanideh, Nader& Nikahval, Behrooz& Mirtalebi, Maryam Sadat& Ahmadi, Nasrollah& Zarea, Shahrokh…[et al.]. 2020. Are Stem Cells Derived from Synovium and Fat Pad Able to Treat Induced Knee Osteoarthritis in Rats?. International Journal of Rheumatology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1173993
Modern Language Association (MLA)
Zare, Reza…[et al.]. Are Stem Cells Derived from Synovium and Fat Pad Able to Treat Induced Knee Osteoarthritis in Rats?. International Journal of Rheumatology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1173993
American Medical Association (AMA)
Zare, Reza& Tanideh, Nader& Nikahval, Behrooz& Mirtalebi, Maryam Sadat& Ahmadi, Nasrollah& Zarea, Shahrokh…[et al.]. Are Stem Cells Derived from Synovium and Fat Pad Able to Treat Induced Knee Osteoarthritis in Rats?. International Journal of Rheumatology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1173993
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173993