Pirfenidone Accelerates Wound Healing in Chronic Diabetic Foot Ulcers: A Randomized, Double-Blind Controlled Trial
Joint Authors
Sánchez-Parada, María G.
Armendáriz-Borunda, Juan
Gasca-Lozano, Luz E.
Lucano-Landeros, Silvia
Ruiz-Mercado, Héctor
Salazar-Montes, Adriana
Sandoval-Rodríguez, Ana
Garcia-Bañuelos, Jesus
Santos-Garcia, Arturo
Davila-Rodriguez, Judith R.
Navarro-Partida, José
Bojórquez-Sepúlveda, Hiram
Castañeda-Gomez, Juan
Domínguez-Rosales, José
Ruiz-Arcos, Myriam A.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Diabetic foot ulcers are one disabling complication of diabetes mellitus.
Pirfenidone (PFD) is a potent modulator of extracellular matrix.
Modified diallyl disulfide oxide (M-DDO) is an antimicrobial and antiseptic agent.
Aim.
To evaluate efficacy of topical PFD + M-DDO in a randomized, double-blind trial versus ketanserin in the treatment of noninfected chronic DFU.
Methods.
Patients received PFD + M-DDO or ketanserin for 6 months.
Relative ulcer volume (RUV) was measured every month; biopsies were taken at baseline and months 1 and 2 for histopathology and gene expression analysis for COL-1α, COL-4, KGF, VEGF, ACTA2 (α-SMA), elastin, fibronectin, TGF-β1, TGF-β3, HIF-1α, and HIF-1β.
Results.
Reduction of median RUV in the PFD + M-DDO group was 62%, 89.8%, and 99.7% at months 1–3 and 100% from months 4 to 6.
Ketanserin reduced RUV in 38.4%, 56%, 60.8%, 94%, 94.8%, and 100% from the first to the sixth month, respectively.
Healing score improved 4.5 points with PFD + M-DDO and 1.5 points with ketanserin compared to basal value.
Histology analysis revealed few inflammatory cells and organized/ordered collagen fiber bundles in PFD + M-DDO.
Expression of most genes was increased with PFD + M-DDO; 43.8% of ulcers were resolved using PFD + M-DDO and 23.5% with ketanserin.
Conclusion.
PFD + M-DDO was more effective than ketanserin in RUV reduction.
American Psychological Association (APA)
Gasca-Lozano, Luz E.& Lucano-Landeros, Silvia& Ruiz-Mercado, Héctor& Salazar-Montes, Adriana& Sandoval-Rodríguez, Ana& Garcia-Bañuelos, Jesus…[et al.]. 2017. Pirfenidone Accelerates Wound Healing in Chronic Diabetic Foot Ulcers: A Randomized, Double-Blind Controlled Trial. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1174072
Modern Language Association (MLA)
Gasca-Lozano, Luz E.…[et al.]. Pirfenidone Accelerates Wound Healing in Chronic Diabetic Foot Ulcers: A Randomized, Double-Blind Controlled Trial. Journal of Diabetes Research No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1174072
American Medical Association (AMA)
Gasca-Lozano, Luz E.& Lucano-Landeros, Silvia& Ruiz-Mercado, Héctor& Salazar-Montes, Adriana& Sandoval-Rodríguez, Ana& Garcia-Bañuelos, Jesus…[et al.]. Pirfenidone Accelerates Wound Healing in Chronic Diabetic Foot Ulcers: A Randomized, Double-Blind Controlled Trial. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1174072
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174072