Soluble Urokinase Receptor and the Kidney Response in Diabetes Mellitus
Joint Authors
Dande, Ranadheer R.
Peev, Vasil
Altintas, Mehmet M.
Reiser, Jochen
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD) worldwide.
DN typically manifests by glomerular hyperfiltration and microalbuminuria; then, the disease progresses to impaired glomerular filtration rate, which leads to ESRD.
Treatment options for DN include the strict control of blood glucose levels and pressure (e.g., intraglomerular hypertension).
However, the search for novel therapeutic strategies is ongoing.
These include seeking specific molecules that contribute to the development and progression of DN to potentially interfere with these “molecular targets” as well as with the cellular targets within the kidney such as podocytes, which play a major role in the pathogenesis of DN.
Recently, podocyte membrane protein urokinase receptor (uPAR) and its circulating form (suPAR) are found to be significantly induced in glomeruli and sera of DN patients, respectively, and elevated suPAR levels predicted diabetic kidney disease years before the occurrence of microalbuminuria.
The intent of this review is to summarize the emerging evidence of uPAR and suPAR in the clinical manifestations of DN.
The identification of specific pathways that govern DN will help us build a more comprehensive molecular model for the pathogenesis of the disease that can inform new opportunities for treatment.
American Psychological Association (APA)
Dande, Ranadheer R.& Peev, Vasil& Altintas, Mehmet M.& Reiser, Jochen. 2017. Soluble Urokinase Receptor and the Kidney Response in Diabetes Mellitus. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1174152
Modern Language Association (MLA)
Dande, Ranadheer R.…[et al.]. Soluble Urokinase Receptor and the Kidney Response in Diabetes Mellitus. Journal of Diabetes Research No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1174152
American Medical Association (AMA)
Dande, Ranadheer R.& Peev, Vasil& Altintas, Mehmet M.& Reiser, Jochen. Soluble Urokinase Receptor and the Kidney Response in Diabetes Mellitus. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1174152
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174152