Clinicopathologic Features and Outcome of Adenocarcinoma of the Anal Canal: A Population-Based Study
Joint Authors
Gachabayov, Mahir
Gogna, Shekhar
Bergamaschi, Roberto
Kajmolli, Agon
Rojas, Aram
Samson, David
Latifi, Rifat
Dong, Xiang (Eric)
Source
International Journal of Surgical Oncology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Anal canal adenocarcinoma (AA) is an uncommon tumor of the gastrointestinal tract.
We seek to provide a detailed description of the incidence, demographics, and outcome of this rare tumor in the United States.
Methods.
The data on anal canal adenocarcinoma from SEER Program, between 1973–2015, were extracted.
We analyzed the incidence rates by demographics and tumor characteristics, followed by analysis of its impact on survival.
Results.
The incidence of AA increased initially by 4.03% yearly from 1973 to 1985 but had a modest decline of 0.32% annually thereafter.
The mean age for diagnosis of AA was 68.12 ± 14.02 years.
Males outnumbered females by 54.8 to 45.2%.
Tumors were mostly localized on presentation (44.4%) and moderately differentiated (41.1%).
Age generally correlated with poor overall cancer survival.
However, young patients (age <40 years) also showed poor long-term survival.
Patients with localized disease and well-differentiated tumors showed better survival outcomes.
Surgical intervention improved survival significantly as compared to patients who did not (116.7 months vs 42.7 months, p<0.01).
Conclusions.
Anal canal adenocarcinoma demonstrated a poor bimodal cancer-free survival in both younger and older patient groups.
Surgery significantly improves odds of survival and should be offered to patients amenable to intervention.
American Psychological Association (APA)
Gogna, Shekhar& Bergamaschi, Roberto& Kajmolli, Agon& Gachabayov, Mahir& Rojas, Aram& Samson, David…[et al.]. 2020. Clinicopathologic Features and Outcome of Adenocarcinoma of the Anal Canal: A Population-Based Study. International Journal of Surgical Oncology،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1174159
Modern Language Association (MLA)
Gogna, Shekhar…[et al.]. Clinicopathologic Features and Outcome of Adenocarcinoma of the Anal Canal: A Population-Based Study. International Journal of Surgical Oncology No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1174159
American Medical Association (AMA)
Gogna, Shekhar& Bergamaschi, Roberto& Kajmolli, Agon& Gachabayov, Mahir& Rojas, Aram& Samson, David…[et al.]. Clinicopathologic Features and Outcome of Adenocarcinoma of the Anal Canal: A Population-Based Study. International Journal of Surgical Oncology. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1174159
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174159