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Serum 25-Hydroxyvitamin D3 Levels Are Associated with Carotid Intima-Media Thickness and Carotid Atherosclerotic Plaque in Type 2 Diabetic Patients
Joint Authors
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
To investigate the relationship between serum 25-hydroxyvitamin D3 [25(OH)D3] levels and carotid intima-media thickness (IMT) as well as carotid atherosclerotic plaque in patients with type 2 diabetes mellitus (T2DM).
Methods.
314 patients with T2DM were enrolled in this study.
The clinical data and laboratory examinations of subjects were recorded, such as serum 25(OH)D3, hemoglobin A1c (HbA1c), serum lipids, fasting blood glucose (FBG), and other biochemical parameters.
Color Doppler ultrasound was used to measure carotid IMT and carotid atherosclerotic plaques.
Patients were divided into four quartile groups according to the serum 25(OH)D3 levels from low to high: group Q1~group Q4.
Results.
From group Q1 to group Q4, carotid IMT and the incidence of plaque were gradually reduced.
Serum 25(OH)D3 levels were lower in the plaque group compared with the nonplaque group (P<0.01).
Serum 25(OH)D3 levels were negatively correlated with the carotid IMT (r=−0.4, P<0.01).
Multiple linear stepwise regression analysis showed that serum 25(OH)D3 was independently associated with carotid IMT (β=−0.009, P<0.01).
Logistic regression analysis showed that serum 25(OH)D3 levels were independently associated with the presence of carotid plaque in T2DM (OR = 0.95; 95%CI: 0.92~0.98, P=0.004).
Conclusions.
Low vitamin D status may contribute to the incidence of carotid atherosclerosis in type 2 diabetic patients.
American Psychological Association (APA)
Wang, Yurong& Zhang, Huijuan. 2017. Serum 25-Hydroxyvitamin D3 Levels Are Associated with Carotid Intima-Media Thickness and Carotid Atherosclerotic Plaque in Type 2 Diabetic Patients. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1174180
Modern Language Association (MLA)
Wang, Yurong& Zhang, Huijuan. Serum 25-Hydroxyvitamin D3 Levels Are Associated with Carotid Intima-Media Thickness and Carotid Atherosclerotic Plaque in Type 2 Diabetic Patients. Journal of Diabetes Research No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1174180
American Medical Association (AMA)
Wang, Yurong& Zhang, Huijuan. Serum 25-Hydroxyvitamin D3 Levels Are Associated with Carotid Intima-Media Thickness and Carotid Atherosclerotic Plaque in Type 2 Diabetic Patients. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1174180
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174180