Effects of Apolipoprotein E Isoforms in Diabetic Nephropathy of Chinese Type 2 Diabetic Patients
Joint Authors
Zhao, Tingting
Li, Ping
Ma, Liang
Liu, Qian
Jiang, Yongwei
Han, ChengWu
Cong, Xiao
Xu, YaPing
Cao, YongTong
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Diabetic nephropathy (DN) is one of the major chronic complications of diabetes.
Genetic polymorphism of Apolipoprotein E (ApoE) has been proposed to participating in DN.
The purpose of the study was to evaluate the relationship between ApoE genetic polymorphism and the presence of DN in Chinese type 2 diabetic patients.
We studied 845 diabetic patients who were divided into DN group (n=429) and control group (n=416).
ApoE genotype was determined by ApoE genotyping chip and the plasmatic biochemical characterization was performed on all subjects.
There were differences (P<0.001) in HbA1c, creatinine, and urinary albumin between the two groups.
The ApoE ε2 allelic frequency was 7.69% in DN group versus 3.49% in control group (OR = 2.22, 95% CI = 1.41–3.47, and P<0.05), as expected, ApoE E2/E2 and E2/E3 genotype frequency were higher in DN group (13.75% versus 6.49%, P<0.05).
The ApoE ε4 allelic frequency was 7.93% in DN group versus 11.54% in control group (OR = 0.70, 95% CI = 0.50–0.97, and P<0.05), and DN group presented a lower frequency of ApoE E3/E4 and E4/E4 genotype frequency (14.91% versus 19.96%, P<0.05).
These results suggest ApoE ε2 allele may be a risk factor; however ApoE ε4 allele may play a protective role of DN in Chinese type 2 diabetic patients.
American Psychological Association (APA)
Jiang, Yongwei& Ma, Liang& Han, ChengWu& Liu, Qian& Cong, Xiao& Xu, YaPing…[et al.]. 2017. Effects of Apolipoprotein E Isoforms in Diabetic Nephropathy of Chinese Type 2 Diabetic Patients. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1174185
Modern Language Association (MLA)
Jiang, Yongwei…[et al.]. Effects of Apolipoprotein E Isoforms in Diabetic Nephropathy of Chinese Type 2 Diabetic Patients. Journal of Diabetes Research No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1174185
American Medical Association (AMA)
Jiang, Yongwei& Ma, Liang& Han, ChengWu& Liu, Qian& Cong, Xiao& Xu, YaPing…[et al.]. Effects of Apolipoprotein E Isoforms in Diabetic Nephropathy of Chinese Type 2 Diabetic Patients. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1174185
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174185